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Titolo:
Brainstem activates paroxysmal discharge in human generalized epilepsy
Autore:
Kohsaka, S; Kohsaka, M; Mizukami, S; Sakai, T; Kobayashi, K;
Indirizzi:
Hokkaido Univ, Sch Med, Dept Pediat, Kita Ku, Sapporo, Hokkaido 060, JapanHokkaido Univ Sapporo Hokkaido Japan 060 Ku, Sapporo, Hokkaido 060, Japan Sapporo Hanazono Hosp, Sapporo, Hokkaido 064, Japan Sapporo Hanazono HospSapporo Hokkaido Japan 064 oro, Hokkaido 064, Japan
Titolo Testata:
BRAIN RESEARCH
fascicolo: 1-2, volume: 903, anno: 2001,
pagine: 53 - 61
SICI:
0006-8993(20010608)903:1-2<53:BAPDIH>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
THALAMIC RETICULAR NUCLEUS; PENICILLIN EPILEPSY; ABSENCE SEIZURES; WAVE DISCHARGE; STEM; NEURONS; SPIKE; SLEEP; SYNCHRONIZATION; POTENTIALS;
Keywords:
poly spike-and-wave complex; ventral brainstem; brainstem auditory evoked potential; excitability change;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
52
Recensione:
Indirizzi per estratti:
Indirizzo: Kohsaka, S Hokkaido Univ, Sch Med, Dept Pediat, Kita Ku, N-15 W-7, Sapporo, Hokkaido 060, Japan Hokkaido Univ N-15 W-7 Sapporo Hokkaido Japan 060 do 060, Japan
Citazione:
S. Kohsaka et al., "Brainstem activates paroxysmal discharge in human generalized epilepsy", BRAIN RES, 903(1-2), 2001, pp. 53-61

Abstract

In nine patients with generalized epilepsy of convulsive seizures, the excitability change of the brainstem was evaluated over the course of the interictal paroxysmal discharge (poly spike-and-wave complex, poly SWC). The evaluation was carried out by a sequential analysis of brainstem auditory evoked potentials (BAEPs) before and during one sequence of poly SWC. The characteristics of BAEPs, i.e. far-field evoked potentials, allowed the evaluation of the excitability change in the brainstem, which was not influenced by the cortical activity. The excitability in the ventral brainstem, measured with the parameters of wave-III, showed a biphasic fluctuation (deceleration-acceleration) before the onset of poly SWC (minima at -0.7 +/-0.4 s). On the other hand, the excitability in the dorsal brainstem, measured with the parameters of wave-V, showed no significant difference over the course of poly SWC. The results suggest that the biphasic excitability change in the ventral brainstem is conveyed to the cortex through the ascending activating system. The excitability acceleration preceded by deceleration in the ventral brainstem probably synchronizes the cortical activity profoundly enough to produce poly SWC through the activation of intralaminar thalamic neurons. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 12:52:29