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Titolo:
Isoindolines: A new series of potent and selective endothelin-A receptor antagonists
Autore:
Kukkola, PJ; Bilci, NA; Ikler, T; Savage, P; Shetty, SS; DelGrande, D; Jeng, AY;
Indirizzi:
Novartis Inst Biomed Res, Summit, NJ 07901 USA Novartis Inst Biomed Res Summit NJ USA 07901 ed Res, Summit, NJ 07901 USA
Titolo Testata:
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
fascicolo: 13, volume: 11, anno: 2001,
pagine: 1737 - 1740
SICI:
0960-894X(20010709)11:13<1737:IANSOP>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
CLONING; RAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Kukkola, PJ Novartis Inst Biomed Res, Summit, NJ 07901 USA Novartis Inst Biomed Res Summit NJ USA 07901 it, NJ 07901 USA
Citazione:
P.J. Kukkola et al., "Isoindolines: A new series of potent and selective endothelin-A receptor antagonists", BIOORG MED, 11(13), 2001, pp. 1737-1740

Abstract

1,3-Disubstituted isoindolines have been discovered as a new class of potent functional ETA selective receptor antagonists through pharmacophore analysis of existing nonpeptide endothelin antagonists. The structure-activity relationships for both the trans and the tis series of isoindolines are discussed. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 11:46:52