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Titolo:
Structures of withanosides I, II, III, IV, V, VI, and VII, new withanolideglycosides, from the roots of Indian Withania somnifera Dunal. and inhibitory activity for tachyphylaxis to clonidine in isolated guinea-pig ileum
Autore:
Matsuda, H; Murakami, T; Kishi, A; Yoshikawa, M;
Indirizzi:
Kyoto Pharmaceut Univ, Yamashima Ku, Kyoto 6078412, Japan Kyoto PharmaceutUniv Kyoto Japan 6078412 shima Ku, Kyoto 6078412, Japan
Titolo Testata:
BIOORGANIC & MEDICINAL CHEMISTRY
fascicolo: 6, volume: 9, anno: 2001,
pagine: 1499 - 1507
SICI:
0968-0896(200106)9:6<1499:SOWIII>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
GASTROINTESTINAL TRANSIT; NITRIC-OXIDE; POSSIBLE INVOLVEMENT; 5-HT2 RECEPTORS; MICE; PROSTAGLANDINS; ACCELERATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Yoshikawa, M Kyoto Pharmaceut Univ, Yamashima Ku, 5 Nakauchi Cho, Kyoto 6078412, Japan Kyoto Pharmaceut Univ 5 Nakauchi Cho Kyoto Japan 6078412 pan
Citazione:
H. Matsuda et al., "Structures of withanosides I, II, III, IV, V, VI, and VII, new withanolideglycosides, from the roots of Indian Withania somnifera Dunal. and inhibitory activity for tachyphylaxis to clonidine in isolated guinea-pig ileum", BIO MED CH, 9(6), 2001, pp. 1499-1507

Abstract

Seven new withanolide glycosides called withanosides I, II, III, IV, V, VI, and VII were isolated from an Indian natural medicine, Ashwagandha, the roots of Indian Withania somnifera DUNAL. (Solanaceae), together with four known compounds, withaferin A, 5 alpha ,20 alpha (F)(R)-dihydroxy-6 alpha ,7alpha -epoxy-1-oxowitha-2,24-dienolide, physagulin D, and coagulin Q. The structures of withanosides I, II, III, IV, V, VI, and VII were determined based on chemical and physicochemical evidence. Principal constituents, withanoside VI (10 and 30 muM) and withaferin A (10 muM), attenuated the tachyphylaxis to clonidine on electrically stimulated guinea-pig ileum in vitro. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 10:59:59