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Titolo:
Aluminum-induced apoptosis in PC12D cells
Autore:
Tsubouchi, R; Htay, HH; Murakami, K; Haneda, M; Yoshino, M;
Indirizzi:
Aichi Med Univ, Sch Med, Dept Biochem, Aichi 4801195, Japan Aichi Med Univ Aichi Japan 4801195 d, Dept Biochem, Aichi 4801195, Japan
Titolo Testata:
BIOMETALS
fascicolo: 2, volume: 14, anno: 2001,
pagine: 181 - 185
SICI:
0966-0844(200106)14:2<181:AAIPC>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALZHEIMERS-DISEASE; LIPID-PEROXIDATION; ACCUMULATION; TOXICITY; BINDING; AL-3+; FE-3+; ION;
Keywords:
aluminum; apoptosis; maltol; PC12; reactive oxygen species;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Yoshino, M Aichi Med Univ, Sch Med, Dept Biochem, Aichi 4801195, Japan Aichi Med Univ Aichi Japan 4801195 chem, Aichi 4801195, Japan
Citazione:
R. Tsubouchi et al., "Aluminum-induced apoptosis in PC12D cells", BIOMETALS, 14(2), 2001, pp. 181-185

Abstract

The addition of aluminum-maltol complex to PC12D cells induced a time-dependent and concentration-dependent growth inhibition as well as cell death, whereas aluminum chloride or maltol alone did not affect the viability of PC12D cells. Apoptosis of differentiated PC12D cells was assessed by using terminal deoxynucleotidyltransferase-mediated 2'-deoxyuridine-5'-triphosphate nick end labeling (TUNEL) technique to detect DNA strand breaks in situ. The number of TUNEL-positive cells treated with aluminum-maltol increased with time in the treatment cultures. The ability of aluminum ion to elevate intracellular reactive oxygen species was determined by fluorescence in PC12D cells loaded with the oxidant-sensitive dye 2',7'-dichlorofluorescin diacetate. Aluminum ion incorporated to PC12D cells causes apoptotic cell death by enhancing the generation of reactive oxygen species.

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Documento generato il 14/07/20 alle ore 11:59:02