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Titolo:
Tumour necrosis factor-alpha is increased in the cerebrospinal fluid and serum of ischaemic stroke patients and correlates with the volume of evolving brain infarct
Autore:
Zaremba, J; Skrobanski, P; Losy, J;
Indirizzi:
Univ Sch Med, Dept Clin Neuroimmunol, PL-60355 Poznan, Poland Univ Sch Med Poznan Poland PL-60355 euroimmunol, PL-60355 Poznan, Poland Univ Sch Med, Dept Neuroradiol, PL-60355 Poznan, Poland Univ Sch Med Poznan Poland PL-60355 Neuroradiol, PL-60355 Poznan, Poland Polish Acad Sci, Inst Expt & Clin Med, Neuroimmunol Unit, PL-60355 Poznan,Poland Polish Acad Sci Poznan Poland PL-60355 unol Unit, PL-60355 Poznan,Poland
Titolo Testata:
BIOMEDICINE & PHARMACOTHERAPY
fascicolo: 5, volume: 55, anno: 2001,
pagine: 258 - 263
SICI:
0753-3322(200106)55:5<258:TNFIII>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
FOCAL CEREBRAL-ISCHEMIA; MACROPHAGE INFLAMMATORY PROTEIN; ADHESION MOLECULES; ENDOTHELIAL-CELLS; TNF-ALPHA; EXPRESSION; CYTOKINES; LOCALIZATION; INJURY; NEURONS;
Keywords:
ischaemic stroke; tumour necrosis factor-alpha;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Zaremba, J Univ Sch Med, Dept Clin Neuroimmunol, 49 Przybyszewskiego St, PL-60355 Poznan, Poland Univ Sch Med 49 Przybyszewskiego St Poznan Poland PL-60355 and
Citazione:
J. Zaremba et al., "Tumour necrosis factor-alpha is increased in the cerebrospinal fluid and serum of ischaemic stroke patients and correlates with the volume of evolving brain infarct", BIOMED PHAR, 55(5), 2001, pp. 258-263

Abstract

A growing body of evidence suggests the involvement of inflammatory mediators, including cytokines, in the development of ischaemic brain lesions. The aim of the present study was to investigate whether tumour necrosis factor-alpha (TNF-alpha), the proinflammatory cytokine, contributes to early pathophysiological mechanisms leading to brain damage as a consequence of acute stroke. We have studied TNF-alpha levels in cerebrospinal fluid (CSF) andserum in 23 stroke patients within the first 24 hours after ischaemic stroke, confirmed by computerized tomography of the brain (CT), The control group consisted of 15 patients with the diagnosis of tension headache and neurasthenia. In stroke patients the levels of TNF-alpha both in CSF and serum were significantly higher in comparison with the control group, The positive correlation between the levels of TNF-alpha in CSF and serum of the studied patients has been observed, Furthermore, a positive correlation between both TNF-alpha levels in CSF and serum and the volume of evolving brain infarct have been shown. (C) 2001 Editions scientifiques et medicales ElsevierSAS.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/10/20 alle ore 05:52:10