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Titolo:
Are child-, adolescent-, and adult-onset depression one and the same disorder?
Autore:
Kaufman, J; Martin, A; King, RA; Charney, D;
Indirizzi:
Yale Univ, Sch Med, Dept Psychiat, New Haven, CT 06511 USA Yale Univ New Haven CT USA 06511 , Dept Psychiat, New Haven, CT 06511 USA Yale Univ, Ctr Child Study, Dept Psychiat, New Haven, CT 06511 USA Yale Univ New Haven CT USA 06511 , Dept Psychiat, New Haven, CT 06511 USA NIMH, Bethesda, MD 20892 USA NIMH Bethesda MD USA 20892NIMH, Bethesda, MD 20892 USA
Titolo Testata:
BIOLOGICAL PSYCHIATRY
fascicolo: 12, volume: 49, anno: 2001,
pagine: 980 - 1001
SICI:
0006-3223(20010615)49:12<980:ACAAAD>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEXAMETHASONE SUPPRESSION TEST; PREPUBERTAL MAJOR DEPRESSION; GROWTH-HORMONE SECRETION; CORTICOTROPIN-RELEASING-FACTOR; THYROID STIMULATING HORMONE; CONTROLLED FAMILY HISTORY; PLACEBO-CONTROLLED TRIAL; DOUBLE-BLIND; NEUROENDOCRINE RESPONSE; CORTISOL SECRETION;
Keywords:
children; adolescents; depression; neurobiology;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
191
Recensione:
Indirizzi per estratti:
Indirizzo: Kaufman, J Yale Univ, Sch Med, Dept Psychiat, Univ Towers Suite 2H,100 York St, New Haven, CT 06511 USA Yale Univ Univ Towers Suite 2H,100 York St New Haven CT USA 06511
Citazione:
J. Kaufman et al., "Are child-, adolescent-, and adult-onset depression one and the same disorder?", BIOL PSYCHI, 49(12), 2001, pp. 980-1001

Abstract

This paper reviews prior research studies examining neurobiological correlates and treatment response of depression in children, adolescents, and adults. Although theta are some similarities in research findings observed across the life cycle, both children and adolescents have been found to differfram depressed adults on measures of basal cortisol sedation, corticotropin stimulation post-corticotropin releasing hormone (CRH) infusion, responsera several serotonergic probes immunity indices, and efficacy; of a tricyclic medications. These differences are proposed to be doe to 1) developmental factors, 2) stage of illness factors (e.g., number of episodes, total duration of illness), or 3) heterogeneity in clinical outcome (e.g., recurrent unipolar course vs. new-onset bipolar disorder). Relevant clinical and preclinical studies that provide support for these alternate explanations of the discrepant findings are reviewed, and directions for future research are discussed. To determine whether child, adolescent-, and adult-onset depression represent the same condition, it is recommended that researchers II use the same neuroimaging paradigms in child, adolescent and adult depressedcohorts; 2) carefully characterize subjects' stage of illness; and 3) conduct longitudinal clinical and repeat neurobiological assessments of patients of diffrrent ages at various stages of illness. In addition careful attention to familial subtypes (e.g., depressive spectrum disorders vs. familialpure depressive disorders) and environmental factors; (e.g., trauma history) are suggested for future investigations, (C) 2001 Society of Biological Psychiatry.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 15:01:26