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Titolo:
Molecular motors and membrane traffic in Dictyostelium
Autore:
Ma, S; Fey, P; Chisholm, RL;
Indirizzi:
Northwestern Univ, Sch Med, Dept Cell & Mol Biol, Chicago, IL 60611 USA Northwestern Univ Chicago IL USA 60611 & Mol Biol, Chicago, IL 60611 USA
Titolo Testata:
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
fascicolo: 3, volume: 1525, anno: 2001,
pagine: 234 - 244
SICI:
0304-4165(20010315)1525:3<234:MMAMTI>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEAVY-CHAIN GENE; KINESIN-LIKE PROTEIN; ACTIN-BASED MOTOR; ANTEROGRADE AXONAL-TRANSPORT; VI UNCONVENTIONAL MYOSIN; CYTOPLASMIC DYNEIN; LIGHT-CHAIN; ENDOPLASMIC-RETICULUM; PHOSPHORYLATION SITES; ORGANELLE TRANSPORT;
Keywords:
membrane traffic; molecular motor; kinesin; dynein; myosin; actin cytoskeleton; microtubule;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
155
Recensione:
Indirizzi per estratti:
Indirizzo: Chisholm, RL Northwestern Univ, Sch Med, Dept Cell & Mol Biol, Chicago, IL60611 USA Northwestern Univ Chicago IL USA 60611 Chicago, IL 60611 USA
Citazione:
S. Ma et al., "Molecular motors and membrane traffic in Dictyostelium", BBA-GEN SUB, 1525(3), 2001, pp. 234-244

Abstract

Phagocytosis and membrane traffic in general are largely dependent on the cytoskeleton and their associated molecular motors. The myosin family of motors, especially the unconventional myosins, interact with the actin cortexto facilitate the internalization of external materials during the early steps of phagocytosis. Members of the kinesin and dynein motor families. which mediate transport along microtubules (MTs), facilitate the intracellularprocessing of the internalized materials and the movement of membrane. Recent studies indicate that some unconventional myosins are also involved in membrane transport. and that the MT- and actin-dependent transport systems might interact with each other. Studies in Dictyostelium have led to the discovery of many motors; involved in critical steps of phagocytosis and membrane transport. With the ease of genetic and biochemical approaches. the established functional analysis to test phagocytosis and vesicle transport, and the effort of the Dictyostelium cDNA and Genome Projects. Dictyostelium will continue to be a superb model system to study phagocytosis in particular and cytoskeleton and motors in general. (C) 2001 Published by Elsevier Science B.V.

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Documento generato il 04/12/20 alle ore 09:16:41