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Titolo:
Cloning and characterization of zfBLP1, a Bcl-XL homologue from the zebrafish, Danio rerio
Autore:
Chen, MC; Gong, HY; Cheng, CY; Wang, JP; Hong, JR; Wu, JL;
Indirizzi:
Acad Sinica, Inst Zool, Lab Marine Mol Biol & Biotechnol, Taipei 115, Taiwan Acad Sinica Taipei Taiwan 115 Mol Biol & Biotechnol, Taipei 115, Taiwan Natl Museum Marine Biol & Aquarium, Dept Planning & Res, Pingtung 944, Taiwan Natl Museum Marine Biol & Aquarium Pingtung Taiwan 944 gtung 944, Taiwan
Titolo Testata:
BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION
fascicolo: 1-2, volume: 1519, anno: 2001,
pagine: 127 - 133
SICI:
0167-4781(20010528)1519:1-2<127:CACOZA>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROGRAMMED CELL-DEATH; INDUCED APOPTOSIS; CYTOCHROME-C; BCL-X(L); FAMILY; MITOCHONDRIA; BAX; MEMBRANE; EXPRESSION; MODULATION;
Keywords:
apoptosis; Bcl-2; Bcl-XL; embryogenesis; zebrafish;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Wu, JL Acad Sinica, Inst Zool, Lab Marine Mol Biol & Biotechnol, Taipei 115, Taiwan Acad Sinica Taipei Taiwan 115 ol & Biotechnol, Taipei 115, Taiwan
Citazione:
M.C. Chen et al., "Cloning and characterization of zfBLP1, a Bcl-XL homologue from the zebrafish, Danio rerio", BBA-GENE ST, 1519(1-2), 2001, pp. 127-133

Abstract

The importance of the Bcl-2 family proteins in normal vertebrate embryogenesis is being recognized; however, their regulatory mechanism is poorly understood. We report here the cloning and characterization of a novel zebrafish Bcl-2 family protein, zfBLP1. The zfBLP1 cDNA is 1942 nucleotides long, encoding a polypeptide of 238 amino acids. The primary sequence of zfBLP1 shares 50% identity to human Bcl-XL, and contains all four conserved BR domains of the Bcl-2 family proteins. Primary sequence analysis identified a consensus ER retention signal at the C-terminal end of zfBLP1. Northern blot analysis indicated that there were two major and two minor zfBLP1 mRNA species expressed during embryonic development. Among the two major mRNA species, the short one, approx. 3 kb in size, was expressed throughout embryonic development, while the long one, approx. 7 kb long, was not detectable until the gastrula stage. These results suggest that zfBLP1 is a novel Bcl-2 family protein under complicated regulations, and is likely to play an important role in zebrafish oogenesis and embryogenesis. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 15:15:58