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Titolo:
Cytokines and cytokine receptors in fetal growth and development
Autore:
Symonds, ME; Mostyn, A; Stephenson, T;
Indirizzi:
Univ Nottingham Hosp, Sch Human Dev, Acad Div Child Hlth, Nottingham NG7 2UH, England Univ Nottingham Hosp Nottingham England NG7 2UH tingham NG7 2UH, England
Titolo Testata:
BIOCHEMICAL SOCIETY TRANSACTIONS
, volume: 29, anno: 2001,
parte:, 2
pagine: 33 - 37
SICI:
0300-5127(200105)29:<33:CACRIF>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
BROWN ADIPOSE-TISSUE; GENE-EXPRESSION; SHEEP FETUS; MATERNAL UNDERNUTRITION; LATE-GESTATION; FACTOR-I; UNCOUPLING PROTEIN; HORMONE SECRETION; PRENATAL EXPOSURE; OVINE FETUS;
Keywords:
growth hormone; leptin; prolactin receptor; uncoupling proteins;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Symonds, ME Univ Nottingham Hosp, Sch Human Dev, Acad Div Child Hlth, Nottingham NG7 2UH, England Univ Nottingham Hosp Nottingham England NG7 2UH 2UH, England
Citazione:
M.E. Symonds et al., "Cytokines and cytokine receptors in fetal growth and development", BIOCH SOC T, 29, 2001, pp. 33-37

Abstract

The cytokine receptors for growth hormone (GH), prolactin and leptin have a critical role in regulating embryo, placental and/or fetal development, which is dependent on stage of gestation and species. GH and prolactin receptors are detectable from conception, and alterations in the maternal hormonal environment may impact on placental growth from this early stage of gestation. Leptin is critical for conception, but its role in fetal growth remains elusive. During late gestation, when fetal growth accelerates and organmaturation occurs, prolactin and insulin-like growth factor-I may have interactive roles in regulating the growth of specific tissues, including adipose tissue. Prolactin, leptin and GH all have specific effects on fetal andneonatal energy balance, which are mediated in part through promoting lipolysis and/or enhancing the expression of uncoupling proteins. An increased understanding of these interactions is likely to have important implications for a number of potentially pathological conditions, including infection,obesity and hypertension.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/04/20 alle ore 21:39:03