Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Role of the System L permease LAT1 in amino acid and iodothyronine transport in placenta
Autore:
Ritchie, JWA; Taylor, PM;
Indirizzi:
Univ Dundee, Sch Life Sci, Div Mol Physiol, Dundee DD1 5EH, Scotland Univ Dundee Dundee Scotland DD1 5EH ol Physiol, Dundee DD1 5EH, Scotland
Titolo Testata:
BIOCHEMICAL JOURNAL
, volume: 356, anno: 2001,
parte:, 3
pagine: 719 - 725
SICI:
0264-6021(20010615)356:<719:ROTSLP>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHORIOCARCINOMA CELL-LINE; THYROID-HORMONE TRANSPORT; HEAVY-CHAIN; FUNCTIONAL-CHARACTERIZATION; MEMBRANE-VESICLES; BRUSH-BORDER; IDENTIFICATION; EXPRESSION; PROTEIN; BEWO;
Keywords:
BeWo cells; membrane transport; System L; triiodothyronine; tryptophan;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Taylor, PM Univ Dundee, Sch Life Sci, Div Mol Physiol, Dundee DD1 5EH, Scotland Univ Dundee Dundee Scotland DD1 5EH Dundee DD1 5EH, Scotland
Citazione:
J.W.A. Ritchie e P.M. Taylor, "Role of the System L permease LAT1 in amino acid and iodothyronine transport in placenta", BIOCHEM J, 356, 2001, pp. 719-725

Abstract

The fete-placental unit relies on a maternal supply of indispensable aminoacids and iodothyronines for early development and normal growth. We examined the role of the System L transporter in placental uptake of these substances, using the human placental choriocarcinoma cell line BeWo as a model experimental system. BeWo cells express both heavy (4F2hc) and light (LAT1,LAT2) chains of the System L holotransporter, Saturable transport of both L-[H-3]tryptophan and [I-125]tri-iodo-L-thyronine in BeWo cells includes components sensitive to inhibition by the System-L-specific substrate 2-endoamino-bicycloheptane-2-carboxylic acid; kinetic properties of these components indicate that the 4F2hc-LAT1 transporter isoform is likely to predominate for the carriage of both substances at physiologically relevant concentrations. Both 4F2hc and LAT1 proteins are also expressed in human placental membranes and LAT1 at least is localized largely to the syncytiotrophoblast layer of the term human placenta. The 4F2hc-LAT1 transporter might therefore serve a vital role in supplying the developing fetus and the placenta with both thyroid hormones and indispensable amino acids from the maternal circulation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/01/21 alle ore 05:53:22