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Titolo:
Antiallergic action of magnolia officinalis on immediate hypersensitivity reaction
Autore:
Shin, TY; Kim, DK; Chae, BS; Lee, EJ;
Indirizzi:
Woosuk Univ, Coll Pharm, Chonju 565701, Chonbuk, South Korea Woosuk Univ Chonju Chonbuk South Korea 565701 65701, Chonbuk, South Korea Woosuk Univ, Coll Sci & Engn, Chonju 565701, Chonbuk, South Korea Woosuk Univ Chonju Chonbuk South Korea 565701 65701, Chonbuk, South Korea Wonkwang Univ, Coll Oriental Med, Iksan 570749, Chonbuk, South Korea Wonkwang Univ Iksan Chonbuk South Korea 570749 0749, Chonbuk, South Korea
Titolo Testata:
ARCHIVES OF PHARMACAL RESEARCH
fascicolo: 3, volume: 24, anno: 2001,
pagine: 249 - 255
SICI:
0253-6269(200106)24:3<249:AAOMOO>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
PASSIVE CUTANEOUS ANAPHYLAXIS; RAT MAST-CELLS; HISTAMINE-RELEASE; MEDIATED ACTIVATION; IMMUNOGLOBULIN-E; HIGH-AFFINITY; SUBSTANCE-P; IGE; RECEPTOR; COMPOUND-48/80;
Keywords:
Magnolia officinalis; immediate hypersensitivity reaction; compound 48/80; anti-DNP IgE; tumor necrosis factor-alpha; cyclic AMP;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Shin, TY Woosuk Univ, Coll Pharm, Chonju 565701, Chonbuk, South Korea Woosuk Univ Chonju Chonbuk South Korea 565701 onbuk, South Korea
Citazione:
T.Y. Shin et al., "Antiallergic action of magnolia officinalis on immediate hypersensitivity reaction", ARCH PH RES, 24(3), 2001, pp. 249-255

Abstract

We studied the effect of aqueous extract of Magnolia officinalis bark (Magnoliaceae) (MOAE) on the immediate hypersensitivity reaction. MOAE (0.01 to1 g/kg) dose-dependently inhibited compound 48/80 induced systemic anaphylaxis in rats. MOAE (0.1 and 1 g/kg) also significantly inhibited local immunoglobulin E (IgE)-mediated passive cutaneous anaphylactic reaction. When MOAE was pretreated at concentrations ranging from 0.01 to 1 g/kg, the levels of plasma histamine were reduced in a dose-dependent manner. MOAE (0.001 to 1 mg/ml) dose-dependently inhibited the histamine release from rat peritoneal mast cells (RPMC) activated by compound 48/80 or anti-dinitrophenyl (DNP) IgE. The level of cyclic AMP (cAMP) in RPMC, when MOAE was added, significantly increased compared with that of the normal control. Moreover, MOAE (0.01 to 1 mg/ml) had a significant inhibitory effect on anti-DNP IgE-induced tumor necrosis factor-alpha production from RPMC. These results indicate that MOAE inhibits immediate hypersensitivity reaction in vivo and in vitro.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 11:03:42