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Titolo:
Phosphatidylserine induces apoptosis in adherent cells
Autore:
Iguchi, K; Hirano, K; Hamatake, M; Ishida, R;
Indirizzi:
Gifu Pharmaceut Univ, Lab Pharmaceut, Gifu 5028585, Japan Gifu Pharmaceut Univ Gifu Japan 5028585 Pharmaceut, Gifu 5028585, Japan Aichi Canc Ctr Hosp, Dept Pharm, Chikusa Ku, Nagoya, Aichi 4648681, Japan Aichi Canc Ctr Hosp Nagoya Aichi Japan 4648681 goya, Aichi 4648681, Japan Aichi Canc Ctr, Res Inst, Lab Chemotherapy, Chikusa Ku, Nagoya, Aichi 4648681, Japan Aichi Canc Ctr Nagoya Aichi Japan 4648681 u, Nagoya, Aichi 4648681, Japan
Titolo Testata:
APOPTOSIS
fascicolo: 4, volume: 6, anno: 2001,
pagine: 263 - 268
SICI:
1360-8185(2001)6:4<263:PIAIAC>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
FOCAL ADHESION KINASE; TYROSINE KINASE; SURFACE; MOVEMENT; DEATH; EXTERNALIZATION; MACROPHAGES; ASYMMETRY; MEMBRANES; SURVIVAL;
Keywords:
phosphatidylserine; adherent cells; detachment; actin filament; protein kinase C;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Hirano, K Gifu Pharmaceut Univ, Lab Pharmaceut, 5-6-1 Mitahora Higashi, Gifu 5028585, Japan Gifu Pharmaceut Univ 5-6-1 Mitahora Higashi Gifu Japan 5028585
Citazione:
K. Iguchi et al., "Phosphatidylserine induces apoptosis in adherent cells", APOPTOSIS, 6(4), 2001, pp. 263-268

Abstract

Phosphatidylserine (PS) is exposed on the outer leaflet of the plasma membrane in apoptotic cell death. However, the roles of PS in apoptotic signaling are still unclear. In this study, we found that exogenous PS, but not other phospholipids, induced cell death in adherent cells, but not in suspension culture. The cell death exhibited typical features of apoptosis such ascell shrinkage, nuclear fragmentation and abnormal chromatin condensation. When PS was added to CHO-K1 cells in monolayer culture, they began to showchanges in cell shape and actin cytoskeleton and protein kinase C (PKC) activity, followed by cell detachment, caspase activation, cleavage of focal adhesion kinase (FAK) and finally loss of viability. These results suggested that PS causes apoptosis through actin disorganization, cell detachment and cleavage of FAK.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 16:23:43