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Titolo:
Hydrogen bonding, base stacking, and steric effects in DNA replication
Autore:
Kool, ET;
Indirizzi:
Stanford Univ, Dept Chem, Stanford, CA 94305 USA Stanford Univ Stanford CA USA 94305 iv, Dept Chem, Stanford, CA 94305 USA
Titolo Testata:
ANNUAL REVIEW OF BIOPHYSICS AND BIOMOLECULAR STRUCTURE
, volume: 30, anno: 2001,
pagine: 1 - 22
SICI:
1056-8700(2001)30:<1:HBBSAS>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
REVERSE-TRANSCRIPTASE; POLYMERASE FIDELITY; AROMATIC STACKING; CRYSTAL-STRUCTURE; GENETIC ALPHABET; HYDROPHOBIC BASE; TEMPLATE-PRIMER; DIFLUOROTOLUENE; THERMODYNAMICS; RECOGNITION;
Keywords:
DNA polymerase; replication fidelity; Watson-Crick hydrogen; bonding;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
63
Recensione:
Indirizzi per estratti:
Indirizzo: Kool, ET Stanford Univ, Dept Chem, Stanford, CA 94305 USA Stanford Univ Stanford CA USA 94305 Chem, Stanford, CA 94305 USA
Citazione:
E.T. Kool, "Hydrogen bonding, base stacking, and steric effects in DNA replication", ANN R BIO B, 30, 2001, pp. 1-22

Abstract

Understanding the mechanisms by which genetic information is replicated isimportant both to basic knowledge of biological organisms and to many useful applications in biomedical research and biotechnology. One of the main functions of a DNA polymerase enzyme is to help DNA recognize itself with high specificity when a strand is being copied. Recent studies have shed new light on the question of what physical forces cause a polymerase enzyme to insert a nucleotide into a strand of DNA and to choose the correct nucleotide over the incorrect ones. This is discussed in the light of three main forces that govern DNA recognition: base stacking, Watson-Crick hydrogen bonding, and steric interactions. These factors are studied with natural and structurally altered DNA nucleosides.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 12:27:55