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Titolo:
Dermal absorption and distribution of C-14 carbaryl in Wistar rats
Autore:
Tos-Luty, S; Tokarska-Rodak, M; Latuszynska, J; Przebirowska, D;
Indirizzi:
Inst Agr Med, Dept Pathomorphol, PL-20950 Lublin, Poland Inst Agr Med Lublin Poland PL-20950 athomorphol, PL-20950 Lublin, Poland
Titolo Testata:
ANNALS OF AGRICULTURAL AND ENVIRONMENTAL MEDICINE
fascicolo: 1, volume: 8, anno: 2001,
pagine: 47 - 50
SICI:
1232-1966(2001)8:1<47:DAADOC>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Keywords:
C-14 carbaryl; dermal absorption; Wistar rats; beta radiation; internal organs; blood;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Tos-Luty, S Inst Agr Med, Dept Pathomorphol, POB 185, PL-20950 Lublin, Poland Inst Agr Med POB 185 Lublin Poland PL-20950 50 Lublin, Poland
Citazione:
S. Tos-Luty et al., "Dermal absorption and distribution of C-14 carbaryl in Wistar rats", ANN AG EN M, 8(1), 2001, pp. 47-50

Abstract

The level of C-14 carbaryl was determined in blood (leukocytes, erythrocytes, ail blood cells, plasma) and organs (brain, heart, lungs, liver, spleen, skin at the: site of exposure) of male Wister rats after dermal administration. The application liquid was C-14 carbaryl solution in 96% ethyl alcohol. This preparation. possessing an activity of 670 kBq/ml, containing 1.67mg of carbaryl, was applied to the skin of the tail according to Massmann's method in own modification. The amount of the preparation per 1 cm(2) of the tail skin was 0.19 mg of carbaryl (74.4 kBq). The rails of experimentalrats were exposed to C-14 carbaryl bp soaking for 4 h daily: once, twice or three times. Beta radiation from C-14 was measured in homogenized organs (brain, heart, lungs, liver, skin) and in blood by computer controlled Wallac scintillation counter Model 1409, using Multi Gale software. The dermal absorption of carbaryl at the site of exposure and in the surrounding area of about 2 cm was observed already during 4 hour exposure. Carbaryl reachedplasma within 4 h of a single dermal exposure and penetrated into leukocytes, erythrocytes, heart, liver, lung, kidney and brain. The largest amount of C-14 carbaryl, about 2% of absorbed dose, was detected in liver.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 14:37:41