Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Hepatitis C and cirrhotic liver disease in the Nile delta of Egypt: A community-based study
Autore:
Darwish, MA; Faris, R; Darwish, N; Shouman, A; Gadallah, M; El-Sharkawy, MS; Edelman, R; Grumbach, K; Rao, MR; Clemens, JD;
Indirizzi:
WHO, Collaborating Ctr Clin Evaluat Vaccines Dev Count, Bethesda, MD USA WHO Bethesda MD USA tr Clin Evaluat Vaccines Dev Count, Bethesda, MD USA NICHHD, Bethesda, MD 20892 USA NICHHD Bethesda MD USA 20892NICHHD, Bethesda, MD 20892 USA Univ Maryland, Sch Med, Div Geog Med, Baltimore, MD USA Univ Maryland Baltimore MD USA Sch Med, Div Geog Med, Baltimore, MD USA Univ Maryland, Sch Med, Dept Radiol, Baltimore, MD 21201 USA Univ Maryland Baltimore MD USA 21201 Dept Radiol, Baltimore, MD 21201 USA Univ Maryland, Sch Med, Ctr Vaccine Dev, Baltimore, MD 21201 USA Univ Maryland Baltimore MD USA 21201 Vaccine Dev, Baltimore, MD 21201 USA Theodor Bilharz Res Inst, Giza, Egypt Theodor Bilharz Res Inst Giza Egypt eodor Bilharz Res Inst, Giza, Egypt Ain Shams Univ, Sch Med, Cairo, Egypt Ain Shams Univ Cairo EgyptAin Shams Univ, Sch Med, Cairo, Egypt
Titolo Testata:
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
fascicolo: 3-4, volume: 64, anno: 2001,
pagine: 147 - 153
SICI:
0002-9637(200103/04)64:3-4<147:HCACLD>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
HIGH SEROPREVALENCE; SCHISTOSOMA-MANSONI; INTERFERON-ALPHA; VIRUS GENOTYPE-4; BLOOD-DONORS; INFECTION; PREVALENCE; RISK;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Rao, MR NICHD, Epidemiol Branch, Div Prevent Res, NIH, 6100 Execut Blvd,Room 7B03,Bethesda, MD 20892 USA NICHD 6100 Execut Blvd,Room 7B03 Bethesda MDUSA 20892 D 20892 USA
Citazione:
M.A. Darwish et al., "Hepatitis C and cirrhotic liver disease in the Nile delta of Egypt: A community-based study", AM J TROP M, 64(3-4), 2001, pp. 147-153

Abstract

Residents of Egypt's Nile river delta have among the world's highest seroprevalence of hepatitis C virus (HCV) infection. To assess the impact of HCVon chronic liver disease, we studied the association between HCV, other hepatitis viruses, and cirrhotic liver disease in a cross-sectional, community-based survey of 801 persons aged greater than or equal to 10 years livingin a semi-urban, Nile delta village. Residents were systematically sampledusing questionnaires, physical examination, abdominal ultrasonography and serologically for antibodies to HCV (confirmed by a third-generation immunoblot assay) and to hepatitis A virus (HAV), hepatitis B virus (HBV), and hepatitis E virus (HEV). The seroprevalence of HCV increased with age from 19% in persons 10-19 years old to about 60% in persons 30 years and older. Although no practices that might facilitate HCV transmission were discovered,the seroprevalence of HCV was significantly associated with remote (> 1 year) histories of schistosomiasis. Sonographic evidence of cirrhosis was present in 3% (95% CI: 1%, 4%) of the population (0.7% of persons under 30 years of age and in 5% of older persons), and was significantly associated with HCV seroreactivity. Our findings are consistent with the hypothesis that past mass parenteral chemotherapy campaigns for schistosomiasis facilitatedHCV transmission, and that HCV may be a major cause of the high prevalenceof liver cirrhosis in this Nile village.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/01/20 alle ore 00:52:39