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Titolo:
Whole-body MR imaging for detection of bone metastases in children and young adults: Comparison with skeletal scintigraphy and FDG PET
Autore:
Daldrup-Link, HE; Franzius, C; Link, TM; Laukamp, D; Sciuk, J; Jurgens, H; Schober, O; Rummeny, EJ;
Indirizzi:
Univ Hosp Munster, Dept Clin Radiol, D-48129 Munster, Germany Univ Hosp Munster Munster Germany D-48129 diol, D-48129 Munster, Germany Univ Hosp Munster, Dept Nucl Med, D-48129 Munster, Germany Univ Hosp Munster Munster Germany D-48129 Med, D-48129 Munster, Germany Univ Hosp Munster, Dept Pediat Ocol, D-48129 Munster, Germany Univ Hosp Munster Munster Germany D-48129 Ocol, D-48129 Munster, Germany
Titolo Testata:
AMERICAN JOURNAL OF ROENTGENOLOGY
fascicolo: 1, volume: 177, anno: 2001,
pagine: 229 - 236
SICI:
0361-803X(200107)177:1<229:WMIFDO>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
SUPERPARAMAGNETIC IRON-OXIDE; SPINAL METASTASES; BREAST-CANCER; YELLOW MARROW; DISEASE; TUMORS; DIPHOSPHONATE; SENSITIVITY; DIAGNOSIS; ACCURACY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Daldrup-Link, HE Tech Univ Munich, Dept Radiol, Ismaninger Str 22, D-81625Munich, Germany Tech Univ Munich Ismaninger Str 22 Munich Germany D-81625
Citazione:
H.E. Daldrup-Link et al., "Whole-body MR imaging for detection of bone metastases in children and young adults: Comparison with skeletal scintigraphy and FDG PET", AM J ROENTG, 177(1), 2001, pp. 229-236

Abstract

Objective. The purpose of this study was to compare the diagnostic accuracy of whole-body MR imaging, skeletal scintigraphy, and 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) for the detection of bone metastases in children. Subjects and methods. Thirty-nine children and young adults who were 2-19 years old and who had Ewing's sarcoma, osteosarcoma, lymphoma, rhabdomyosarcoma, melanoma, and Langerhans' cell histiocytosis underwent whole-body spin-echo MR imaging, skeletal scintigraphy, and FDG PET for the initial staging of bone marrow metastases. The number and location of bone and bone marrow lesions diagnosed with each imaging modality were correlated with biopsyand clinical follow-up as the standard of reference. Results. Twenty-one patients exhibited 51 bone metastases. Sensitivities for the detection of bone metastases were 90% for FDG PET, 82% for whole-body MR imaging, and 71% for skeletal scintigraphy; these data were significantly different (p < 0.05). False-negative lesions were different for the three imaging modalities, mainly depending on lesion location. Most false-positive lesions were diagnosed using FDG PET. Conclusion. Whole-body MR imaging has a higher sensitivity than skeletal scintigraphy for the detection of bone marrow metastases but a lower sensitivity than FDG PET.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/21 alle ore 11:18:40