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Titolo:
Functional characterization of basolateral and luminal dopamine receptors in rabbit CCD
Autore:
Saito, O; Ando, Y; Kusano, E; Asano, Y;
Indirizzi:
Jichi Med Sch, Dept Med, Div Nephrol, Minami Kawachi, Tochigi 3290498, Japan Jichi Med Sch Minami Kawachi Tochigi Japan 3290498 Tochigi 3290498, Japan
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
fascicolo: 1, volume: 281, anno: 2001,
pagine: F114 - F122
SICI:
0363-6127(200107)281:1<F114:FCOBAL>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORTICAL COLLECTING DUCT; MOLECULAR-BIOLOGY; TUBULE CELLS; RENAL TUBULE; RAT-KIDNEY; VASOPRESSIN; TRANSPORT; PHARMACOLOGY; MECHANISMS; AGONIST;
Keywords:
in vitro microperfusion; transepithelial voltage; dopamine receptor; sodium transport; cortical collecting duct;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Ando, Y Jichi Med Sch, Dept Med, Div Nephrol, 3311-1 Yakushiji, Minami Kawachi, Tochigi 3290498, Japan Jichi Med Sch 3311-1 Yakushiji Minami Kawachi Tochigi Japan 3290498
Citazione:
O. Saito et al., "Functional characterization of basolateral and luminal dopamine receptors in rabbit CCD", AM J P-REN, 281(1), 2001, pp. F114-F122

Abstract

Previous studies reported the existence of both D-1- and D-2-like receptors in the cortical collecting duct (CCD). However, especially with regard tonatriuresis, it remains controversial. In the present study, rabbit CCD was perfused to characterize the receptor subtypes responsible for the tubular actions. Basolateral dopamine (DA) induced a dose-dependent depolarization of transepithelial voltage. Basolateral domperidone, a D-2-like receptor antagonist, abolished depolarization, whereas SKF-81297, a D(1-)like receptor agonist, showed no significant change. In addition, bromocriptine, a D-2-like receptor agonist, also caused depolarization, whereas SKF-81297, a D-1-like receptor agonist, did not depolarize significantly. Moreover, RBI-257, a D-4-specific antagonist, reversed the basolateral DA-induced depolarization. In contrast to the basolateral side, luminal DA caused depolarization via a D-1-like receptor; however the change was less than that for basolateral DA. For further evaluation, Na-22(+) flux (J(Na)) was measured to confirm the effect of DA on Na+ transport. Basolateral DA also caused a suppression of J(Na), and this reaction was abolished by domperidone. These results suggested that the basolateral D-2-like receptor is mainly responsible for the natriuretic action of DA in rabbit CCD.

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Documento generato il 29/09/20 alle ore 23:19:40