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Titolo:
Factors that increase the contractile tone of the ductus arteriosus also regulate its anatomic remodeling
Autore:
Kajino, H; Chen, YQ; Seidner, SR; Waleh, N; Mauray, F; Roman, C; Chemtob, S; Koch, CJ; Clyman, RI;
Indirizzi:
Univ Calif San Francisco, Cardiovasc Res Inst, HSE 1492, San Francisco, CA94143 USA Univ Calif San Francisco San Francisco CA USA 94143 rancisco, CA94143 USA Univ Calif San Francisco, Dept Pediat, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA SRI Int, Menlo Park, CA 94025 USA SRI Int Menlo Park CA USA 94025SRI Int, Menlo Park, CA 94025 USA Univ Texas, Hlth Sci Ctr, Dept Pediat, San Antonio, TX 78284 USA Univ Texas San Antonio TX USA 78284 ept Pediat, San Antonio, TX 78284 USA Hop St Justine, Ctr Rech, Montreal, PQ H3T 1C5, Canada Hop St Justine Montreal PQ Canada H3T 1C5 h, Montreal, PQ H3T 1C5, Canada Univ Penn, Dept Radiat Oncol, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 iat Oncol, Philadelphia, PA 19104 USA
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
fascicolo: 1, volume: 281, anno: 2001,
pagine: R291 - R301
SICI:
0363-6119(200107)281:1<R291:FTITCT>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOTHELIAL GROWTH-FACTOR; NITRIC-OXIDE; FACTOR EXPRESSION; FACTOR GENE; TUMOR ANGIOGENESIS; VASA VASORUM; FACTOR-BETA; FETAL LAMB; OXYGEN; INDOMETHACIN;
Keywords:
hypoxia; nitric oxide; prostaglandins; oxygen; newborn;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Clyman, RI Univ Calif San Francisco, Cardiovasc Res Inst, HSE 1492, Box 0544, San Francisco, CA 94143 USA Univ Calif San Francisco Box 0544 San Francisco CA USA 94143 SA
Citazione:
H. Kajino et al., "Factors that increase the contractile tone of the ductus arteriosus also regulate its anatomic remodeling", AM J P-REG, 281(1), 2001, pp. R291-R301

Abstract

Permanent closure of the full-term newborn ductus arteriosus (DA) occurs only if profound hypoxia develops within the vessel wall during luminal obliteration. We used fetal and newborn baboons and lambs to determine why the immature DA fails to remodel after birth. When preterm newborns were kept in a normoxic range (PaO2 : 50-90 mmHg), 86% still had a small patent DA on the sixth day after birth; in addition, the preterm DA wall was only mildlyhypoxic and had only minimal remodeling. The postnatal increase in PaO2 normally induces isometric contractile responses in rings of DA; however, theexcessive inhibitory effects of endogenous prostaglandins and nitric oxide, coupled with a weaker intrinsic DA tone, make the preterm DA appear to have a smaller increment in tension in response to oxygen than the DA near term. We found that oxygen concentrations, beyond the normoxic range, producean additional increase in tension in the preterm DA that is similar to thecontractile response normally seen at term. We predicted that preterm newborns, kept at a higher PaO2, would have increased DA tone and would be morelikely to obliterate their lumen. We found that preterm newborns, maintained at a PaO2 >200 mmHg, had only a 14% incidence of patent DA. Even though DA constriction was due to elevated PaO2, obliteration of the lumen produced profound hypoxia of the DA wall and the same features of remodeling that were observed at term. DA wall hypoxia appears to be both necessary and sufficient to produce anatomic remodeling in preterm newborns.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 01:06:31