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Titolo:
Hemodynamic response pattern predicts susceptibility to stress-induced elevation in arterial pressure in the rat
Autore:
Muller, JR; Le, KM; Haines, WR; Gan, Q; Knuepfer, MM;
Indirizzi:
St Louis Univ, Sch Med, Dept Pharmacol & Physiol Sci, St Louis, MO 63104 USA St Louis Univ St Louis MO USA 63104 & Physiol Sci, St Louis, MO 63104 USA
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
fascicolo: 1, volume: 281, anno: 2001,
pagine: R31 - R37
SICI:
0363-6119(200107)281:1<R31:HRPPST>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
CARDIAC-OUTPUT RESPONSES; CARDIOVASCULAR-RESPONSE; BLOOD-PRESSURE; CONSCIOUS RATS; MENTAL STRESS; HYPERTENSIVE PARENTS; VASCULAR-RESPONSES; COCAINE; REACTIVITY; AMERICANS;
Keywords:
behavioral stress; cardiac output; systemic vascular resistance;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Knuepfer, MM St Louis Univ, Sch Med, Dept Pharmacol & Physiol Sci, 1402 S Grant Blvd, St Louis, MO 63104 USA St Louis Univ 1402 S Grant Blvd St LouisMO USA 63104 104 USA
Citazione:
J.R. Muller et al., "Hemodynamic response pattern predicts susceptibility to stress-induced elevation in arterial pressure in the rat", AM J P-REG, 281(1), 2001, pp. R31-R37

Abstract

Cocaine or air jet stress evokes pressor responses due to either a large increase in systemic vascular resistance (vascular responders) or small increases in both cardiac output and vascular resistance (mixed responders) in conscious rats. Repeated cocaine administration results in elevated arterial pressure in vascular responders but not in mixed responders. The present study examined the hypothesis that the pattern of cardiovascular responses to an unconditioned stimulus (UCS; air jet) is related to responses to a conditioned stimulus (CS; tone followed by brief foot shock) in individual rats. Our data demonstrate that presentation of the UCS produced variable cardiac output responses that correlated with responses to the CS (n = 60). Wealso determined whether individual cardiovascular response patterns to acute stress correlated with predisposition to a sustained stress-induced elevation in arterial pressure. Rats were exposed to three different stressors presented one per day successively for 4 wk and during a poststress period of 3 wk while arterial pressure was recorded periodically. Mean arterial pressure was elevated in all rats during chronic stress but, during the poststress period, remained at significantly higher levels in vascular responders but not mixed responders. Therefore, we conclude that acute behavioral stress to a conditioned stimulus elicits variable hemodynamic responses that predict the predisposition to a sustained stress-induced elevation in arterial pressure.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 10:21:03