Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Nitric oxide modulates capillary formation at the endothelial cell-tumor cell interface
Autore:
Phillips, PG; Birnby, LM; Narendran, A; Milonovich, WL;
Indirizzi:
Samuel S Stratton Vet Affairs Med Ctr, Res Serv, Albany, NY 12208 USA Samuel S Stratton Vet Affairs Med Ctr Albany NY USA 12208 y, NY 12208 USA Albany Med Coll, Dept Med, Albany, NY 12208 USA Albany Med Coll Albany NYUSA 12208 Coll, Dept Med, Albany, NY 12208 USA Albany Med Coll, Ctr Cardiovasc Sci, Albany, NY 12208 USA Albany Med CollAlbany NY USA 12208 Cardiovasc Sci, Albany, NY 12208 USA Albany Med Coll, Ctr Cell Biol & Canc Res, Albany, NY 12208 USA Albany MedColl Albany NY USA 12208 Biol & Canc Res, Albany, NY 12208 USA
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
fascicolo: 1, volume: 281, anno: 2001,
pagine: L278 - L290
SICI:
1040-0605(200107)281:1<L278:NOMCFA>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
FIBROBLAST-GROWTH-FACTOR; LUNG-CANCER; IN-VIVO; SYNTHASE ACTIVITY; ANGIOGENESIS; PROGRESSION; EXPRESSION; METASTASIS; INDUCTION; PROLIFERATION;
Keywords:
angiogenesis; CD31/platelet endothelial cell adhesion molecule; matrix metalloproteinases; focal adhesion kinase; protein tyrosine phosphorylation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
57
Recensione:
Indirizzi per estratti:
Indirizzo: Phillips, PG Samuel S Stratton Vet Affairs Med Ctr, Res Serv, 151D,113 Holland Ave, Albany, NY 12208 USA Samuel S Stratton Vet Affairs Med Ctr 151D,113 Holland Ave Albany NY USA 12208
Citazione:
P.G. Phillips et al., "Nitric oxide modulates capillary formation at the endothelial cell-tumor cell interface", AM J P-LUNG, 281(1), 2001, pp. L278-L290

Abstract

Nitric oxide synthase expression has been documented in lung tumors, but apotential role for nitric oxide (NO) in induction of capillary formation remains to be elucidated. The purpose of this report was to characterize thedirect effects of NO at the level of the tumor-endothelium interface with respect to angiogenesis. A Transwell two-compartment culture system, human endothelial cells (EC), and two human non-small cell lung cancer (CA) linesthat constitutively produce NO were used to simulate the EC-tumor cell interface. Both histological types of lung CA, squamous and adenocarcinoma, induced baseline capillary formation by EC within 3 days. This process was inhibited by NO in the microenvironment because decreasing NO production with100 muM aminoguanidine (AG) significantly increased capillary formation, whereas coincubation with 100 muM AG plus 400 muM L-arginine returned angiogenesis to baseline values. We demonstrate further that NO may exert its inhibitory effects by influencing matrix metalloproteinase expression/activityand tyrosine phoshorylation of proteins in the sprouting tips of nascent capillaries.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/09/20 alle ore 18:45:09