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Titolo:
Frequency dependence of endocytosis in aortic baroreceptor neurons and role of group III mGluRs
Autore:
Pamidimukkala, J; Hay, M;
Indirizzi:
Univ Missouri, Dalton Cardiovasc Res Ctr, Columbia, MO 65211 USA Univ Missouri Columbia MO USA 65211 ovasc Res Ctr, Columbia, MO 65211 USA Univ Missouri, Dept Biomed Sci, Columbia, MO 65211 USA Univ Missouri Columbia MO USA 65211 pt Biomed Sci, Columbia, MO 65211 USA
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
fascicolo: 1, volume: 281, anno: 2001,
pagine: H387 - H395
SICI:
0363-6135(200107)281:1<H387:FDOEIA>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
METABOTROPIC GLUTAMATE RECEPTORS; NUCLEUS-TRACTUS-SOLITARIUS; FROG NEUROMUSCULAR-JUNCTION; MOTOR-NERVE TERMINALS; RETINAL BIPOLAR CELLS; SYNAPTIC TRANSMISSION; TRANSMITTER RELEASE; POSTTETANIC POTENTIATION; HIPPOCAMPAL SYNAPSES; RAT HIPPOCAMPUS;
Keywords:
FM1-43; synaptic transmission; nodose ganglia; metabotropic glutamate receptors;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: Hay, M Univ Missouri, Dalton Cardiovasc Res Ctr, 134 Res Pk, Columbia, MO 65211 USA Univ Missouri 134 Res Pk Columbia MO USA 65211 lumbia, MO 65211 USA
Citazione:
J. Pamidimukkala e M. Hay, "Frequency dependence of endocytosis in aortic baroreceptor neurons and role of group III mGluRs", AM J P-HEAR, 281(1), 2001, pp. H387-H395

Abstract

Synaptic transmission between baroreceptor afferents and the nucleus tractus solitarius (NTS) is known to exhibit frequency-dependent depression. Reductions in neurotransmitter release and alterations in mechanisms regulating synaptic transmission are hypothesized to be involved in the activity-dependent depression observed in baroreceptor afferent neurons. The present study utilized cultured aortic baroreceptor neurons and the fluorescent dyes FM1-43 and FM2-10 to characterize the process of endocytosis or vesicle retrieval and its dependence on 1) frequency of neuronal activation, 2) metabotropic glutamate receptor (mGluR) activation, and 3) calcium concentrationsinside and outside the cell. Endocytosis per spike, measured in fluorescence units after a 10-s stimulus applied at frequencies of 0.5 (53 +/- 4), 1.0 (23 +/- 1), and 10.0 Hz (2.7 +/- 0.2), was significantly depressed at higher frequencies. Blockade of group III mGluRs with (RS)-cyclopropyl-4-phosphonophenyl-glycine (CPPG) facilitated endocytosis at all frequencies, suggesting that this receptor subtype may be involved in the inhibition of endocytosis. Manipulating the extracellular and intracellular calcium concentrations subsequent to exocytosis had no effect on endocytosis. These results suggest that frequency-dependent depression of endocytosis observed in vitrocould contribute to the frequency-dependent depression of baroreceptor afferent neurotransmission and that group III mGluRs inhibit endocytosis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 16:01:47