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Titolo:
In vivo assessment of acetylcholine-releasing function at cardiac vagal nerve terminals
Autore:
Kawada, T; Yamazaki, T; Akiyama, T; Shishido, T; Inagaki, M; Uemura, K; Miyamoto, T; Sugimachi, M; Takaki, H; Sunagawa, K;
Indirizzi:
Natl Cardiovasc Ctr, Res Inst, Dept Cardiovasc Dynam, Osaka 5658565, JapanNatl Cardiovasc Ctr Osaka Japan 5658565 vasc Dynam, Osaka 5658565, Japan Natl Cardiovasc Ctr, Res Inst, Dept Cardiac Physiol, Osaka 5658565, Japan Natl Cardiovasc Ctr Osaka Japan 5658565 ac Physiol, Osaka 5658565, Japan
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
fascicolo: 1, volume: 281, anno: 2001,
pagine: H139 - H145
SICI:
0363-6135(200107)281:1<H139:IVAOAF>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT ATRIA; CAT; OUABAIN; CHOLINE; TRANSMISSION; STIMULATION; VENTRICLES; MECHANISM; RECEPTOR; NEURONS;
Keywords:
cardiac microdialysis; high K+; ouabain; arterial baroreflex; Bezold-Jarisch reflex;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Kawada, T Natl Cardiovasc Ctr, Res Inst, Dept Cardiovasc Dynam, 5-7-1 Fujishirodai, Osaka 5658565, Japan Natl Cardiovasc Ctr 5-7-1 Fujishirodai Osaka Japan 5658565 apan
Citazione:
T. Kawada et al., "In vivo assessment of acetylcholine-releasing function at cardiac vagal nerve terminals", AM J P-HEAR, 281(1), 2001, pp. H139-H145

Abstract

We examined whether the ACh concentration measured by cardiac microdialysis provided information on left ventricular ACh levels under a variety of vagal stimulatory and modulatory conditions in anesthetized cats. Local administration of KCl (n = 5) and ouabain (n = 7) significantly increased the ACh concentration in the dialysate to 4.3 +/- 0.8 and 7.3 =/- 1.3 nmol/l, respectively, from the baseline value of 0.6 +/- 0.5 nmol/l. Intravenous administration of phenylbiguanide (n = 5) and phenylephrine (n = 6) significantly increased the ACh concentration to 5.4 +/- 0.9 and 6.0 +/- 1.5 nmol/l, respectively, suggesting that the Bezold-Jarisch and arterial baroreceptor reflexes affected myocardial ACh levels. Modulation of vagal nerve terminal function by local administration of tetrodotoxin (n = 6), hemicholinium-3 (n= 6), and vesamicol (n = 5) significantly suppressed the electrical stimulation-induced ACh release from 20.4 +/- 3.9 to 0.6 +/- 0.1, 7.2 +/- 1.9, and 2.7 +/- 0.6 nmol/l, respectively. Increasing the heart rate from 120 to 200 beats/min significantly reduced the myocardial ACh levels during electrical vagal stimulation, suggesting a heart rate-dependent washout of ACh. Weconclude that ACh concentration measured by cardiac microdialysis providesinformation regarding ACh release and disposition under a variety of pathophysiological conditions in vivo.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 23:49:06