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Titolo:
Endothelin-1 and nitric oxide synthase in short rebound reaction to short exposure to inhaled nitric oxide
Autore:
Chen, L; He, H; Mondejar, EF; Freden, F; Wiklund, P; Alving, K; Hedenstierna, G;
Indirizzi:
Univ Uppsala Hosp, Dept Clin Physiol, S-75185 Uppsala, Sweden Univ UppsalaHosp Uppsala Sweden S-75185 hysiol, S-75185 Uppsala, Sweden Univ Uppsala Hosp, Dept Anesthesiol & Intens Care, S-75185 Uppsala, SwedenUniv Uppsala Hosp Uppsala Sweden S-75185 s Care, S-75185 Uppsala, Sweden Karolinska Inst, Dept Urol, S-17176 Stockholm, Sweden Karolinska Inst Stockholm Sweden S-17176 Urol, S-17176 Stockholm, Sweden Karolinska Inst, Dept Physiol & Pharmacol, S-17176 Stockholm, Sweden Karolinska Inst Stockholm Sweden S-17176 acol, S-17176 Stockholm, Sweden
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
fascicolo: 1, volume: 281, anno: 2001,
pagine: H124 - H131
SICI:
0363-6135(200107)281:1<H124:EANOSI>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERSISTENT PULMONARY-HYPERTENSION; ENDOTOXIN-SHOCK; LUNG; INHALATION; NEWBORN; CELLS; RELEASE; EXPRESSION; THERAPY; RATS;
Keywords:
endotoxin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Hedenstierna, G Univ Uppsala Hosp, Dept Clin Physiol, S-75185 Uppsala, Sweden Univ Uppsala Hosp Uppsala Sweden S-75185 Uppsala, Sweden
Citazione:
L. Chen et al., "Endothelin-1 and nitric oxide synthase in short rebound reaction to short exposure to inhaled nitric oxide", AM J P-HEAR, 281(1), 2001, pp. H124-H131

Abstract

On withdrawal of inhalation of nitric oxide (INO) administered after lung injury, pulmonary artery pressure (PAP) and arterial oxygen tension (Pa-O2)may deteriorate more than before INO (rebound response). In this study, weinvestigated the possible roles of endothelin (ET)-1 and nitric oxide (NO)synthase (NOS) activity in the short rebound reaction to short-term inhalation of NO. Twenty-six anesthetized mechanically ventilated piglets were given endotoxin infusion. Twelve animals then received INO (30 parts per million) for two 30-min periods. Nine controls were not given NO. Measurements were made of blood gases and hemodynamic parameters, lung tissue ET-1 expression and NOS activity, and plasma ET-1 concentration. INO decreased PAP and increased Pa-O2, but INO withdrawal caused a short rebound reaction with an increase in PAP. Lung tissue expression and plasma concentration of ET-1increased during INO, and plasma ET-1 increased further after its withdrawal. Activity of constitutive NOS decreased during INO, whereas that of inducible NOS was unchanged. Upregulation of ET-1 and downregulation of NOS activity may have influenced the short rebound reaction to short-term INO.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 09:31:33