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Titolo:
HMG-CoA reductase inhibitor stabilizes rabbit atheroma by increasing basalNO and decreasing superoxide
Autore:
Thakur, NK; Hayashi, T; Sumi, D; Kano, H; Tsunekawa, T; Iguchi, A;
Indirizzi:
Nagoya Univ, Grad Sch Med, Dept Geriatr, Showa Ku, Nagoya, Aichi 4668550, Japan Nagoya Univ Nagoya Aichi Japan 4668550 a Ku, Nagoya, Aichi 4668550, Japan
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
fascicolo: 1, volume: 281, anno: 2001,
pagine: H75 - H83
SICI:
0363-6135(200107)281:1<H75:HRISRA>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
NITRIC-OXIDE SYNTHASE; ENDOTHELIUM-DEPENDENT RELAXATION; CHOLESTEROL-FED RABBITS; LOW-DENSITY-LIPOPROTEIN; ATHEROSCLEROTIC LESIONS; REGRESSION; PEROXYNITRITE; PLAQUE; MACROPHAGES; DISMUTASE;
Keywords:
atherosclerosis; stabilization; superoxide anion; nitric oxide synthase; hyperlipidemia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Hayashi, T Nagoya Univ, Grad Sch Med, Dept Geriatr, Showa Ku, 65 Tsuruma Cho, Nagoya,Aichi 4668550, Japan Nagoya Univ 65 Tsuruma Cho Nagoya Aichi Japan 4668550 50, Japan
Citazione:
N.K. Thakur et al., "HMG-CoA reductase inhibitor stabilizes rabbit atheroma by increasing basalNO and decreasing superoxide", AM J P-HEAR, 281(1), 2001, pp. H75-H83

Abstract

Male rabbits fed a 0.5% cholesterol diet for 8 wk were divided into three groups. Group 1 was hypercholesterolemic; group 2 was fed a regular diet for an additional 12 wk; and group 3 was fed a regular diet with simvastatin (5 mg . kg(-1) . day(-1)). Simvastatin treatment reduced the atherosclerotic area and total and esterified cholesterol concentrations in the thoracic aorta. Tone-related basal nitric oxide (NO) release was highest in group 3. Acetylcholine-induced, NO-dependent relaxation was improved in group 3 compared with group 2. Amount of endothelial nitric oxide synthase (eNOS) mRNAin vessels increased in group 1, compared with normal aorta, and decreasedin group 2; however, it did not decrease in group 3. The amount of O-2(-) released from vessels increased in group 1 and group 2 compared with normalrabbits; however, it decreased in group 3, especially in the endothelial cells. Peroxynitrite determined by nitrotyrosine staining decreased in group3. Additionally, the arteries of rabbits fed a regular diet with or without simvastatin were investigated. The aorta from simvastatin-treated group showed increase of tone-related basal NO release and eNOS mRNA and decrease of O-2(-) release. Taken together, upregulation of eNOS and decrease of O-2(-) treatment were observed in vivo in the process of the sufficient stabilization of atheroma following simvastatin.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 01:37:19