Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Neural change in Trichinella-infected mice is MHC II independent and involves M-CSF-derived macrophages
Autore:
Galeazzi, F; Lovato, P; Blennerhassett, PA; Haapala, EM; Vallance, BA; Collins, SM;
Indirizzi:
McMaster Univ, Med Ctr, Intestinal Dis Res Program, Hamilton, ON L8N 3Z5, Canada McMaster Univ Hamilton ON Canada L8N 3Z5 am, Hamilton, ON L8N 3Z5, Canada McMaster Univ, Gastrointestinal Div, Hamilton, ON L8N 3Z5, Canada McMasterUniv Hamilton ON Canada L8N 3Z5 iv, Hamilton, ON L8N 3Z5, Canada McMaster Univ, Hlth Sci Ctr, Dept Med, Hamilton, ON L8N 3Z5, Canada McMaster Univ Hamilton ON Canada L8N 3Z5 ed, Hamilton, ON L8N 3Z5, Canada Univ Padua, Dept Surg & Gastroenterol Sci, Gastroenterol Sect, I-35131 Padua, Italy Univ Padua Padua Italy I-35131 Gastroenterol Sect, I-35131 Padua, Italy
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
fascicolo: 1, volume: 281, anno: 2001,
pagine: G151 - G158
SICI:
0193-1857(200107)281:1<G151:NCITMI>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT MYENTERIC PLEXUS; NECROSIS-FACTOR-ALPHA; ACETYLCHOLINE-RELEASE; DENDRITIC CELLS; NERVE FUNCTION; OP/OP MOUSE; T-CELLS; EXPRESSION; INTERLEUKIN-1-BETA; OSTEOPETROSIS;
Keywords:
macrophage colony-stimulating factor; op/op mice; nematode; enteric nerves; inflammatory bowel disease;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Collins, SM McMaster Univ, Med Ctr, Intestinal Dis Res Program, Rm 4W8, Hamilton, ON L8N 3Z5, Canada McMaster Univ Rm 4W8 Hamilton ON Canada L8N 3Z5 8N 3Z5, Canada
Citazione:
F. Galeazzi et al., "Neural change in Trichinella-infected mice is MHC II independent and involves M-CSF-derived macrophages", AM J P-GAST, 281(1), 2001, pp. G151-G158

Abstract

Intestinal inflammation due to nematode infection impairs enteric cholinergic nerve function and induces hypercontractility of intestinal muscle. Macrophages have been implicated in the neural changes, but the subpopulation and mechanism involved are unknown. We examined whether macrophages alter nerves by virtue of their ability to activate lymphocytes via major histocompatibility complex (MHC) II-restricted antigen presentation. We also attempted to evaluate the role of macrophage subsets using op/op mice deficient in macrophage colony-stimulating factor (M-CSF). ACh release from the myenteric plexus was measured in MHC II- and M-CSF-deficient (op/op) mice infected with Trichinella spiralis. F4/80-positive macrophages and interleukin-1 beta were constitutively present in op/op and op/? mice but increased only in op/? mice postinfection. After infection, a marked suppression of ACh release occurred only in infected MHC II- deficient and op/? mice. Muscle hypercontractility remained evident in infected op/? mice. Treatment with M-CSFrestored macrophage number, and this was accompanied by suppression of cholinergic nerve function during infection. Thus M-CSF plays a critical role in this model by recruiting a subset of macrophages that selectively suppresses enteric neural function.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/04/20 alle ore 23:48:38