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Titolo:
Effect of the GABA(A) agonist gaboxadol on nocturnal sleep and hormone secretion in healthy elderly subjects
Autore:
Lancel, M; Wetter, TC; Steiger, A; Mathias, S;
Indirizzi:
Max Planck Inst Psychiat, D-80804 Munich, Germany Max Planck Inst Psychiat Munich Germany D-80804 D-80804 Munich, Germany
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
fascicolo: 1, volume: 281, anno: 2001,
pagine: E130 - E137
SICI:
0193-1849(200107)281:1<E130:EOTGAG>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
NON-REM SLEEP; DELTA-ACTIVITY; YOUNG-ADULT; NORMAL MEN; THIP; EEG; DISORDERS; EPIDEMIOLOGY; DEPRIVATION; HUMANS;
Keywords:
gamma-aminobutyric acid(A) receptor; growth hormone; hypothalamic pituitary-adrenocortical axis; sleep-electroencephalogram spectral analysis; aging;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Lancel, M Max Planck Inst Psychiat, Kraepelinstr 2, D-80804 Munich, Germany Max Planck Inst Psychiat Kraepelinstr 2 Munich Germany D-80804
Citazione:
M. Lancel et al., "Effect of the GABA(A) agonist gaboxadol on nocturnal sleep and hormone secretion in healthy elderly subjects", AM J P-ENDO, 281(1), 2001, pp. E130-E137

Abstract

Aging is associated with a dramatic decrease in sleep intensity and continuity. The selective GABAA receptor agonist gaboxadol has been shown to increase non-REM sleep and the duration of the non-REM episodes in rats and sleep efficiency in young subjects and to enhance low-frequency activity in the electroencephalogram (EEG) within non-REM sleep in both rats and humans. In this double-blind, placebo-controlled study, we investigated the influence of an oral dose of 15 mg of gaboxadol on nocturnal sleep and hormone secretion (ACTH, cortisol, prolactin, growth hormone) in 10 healthy elderly subjects (6 women). Compared with placebo, gaboxadol did not affect endocrineactivity but significantly reduced perceived sleep latency, elevated self-estimated total sleep time, and increased sleep efficiency by decreasing intermittent wakefulness and powerfully augmented low-frequency activity in the EEG within non-REM sleep. These findings indicate that gaboxadol is ableto increase sleep consolidation and non-REM sleep intensity, without disrupting REM sleep, in elderly individuals and that these effects are not mediated by a modulation of hormone secretion.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 18:00:56