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Titolo:
Anti-adrenergic effects of nitric oxide donor SIN-1 in rat cardiac myocytes
Autore:
Stojanovic, MO; Ziolo, MT; Wahler, GM; Wolska, BM;
Indirizzi:
Univ Illinois, Dept Med, Cardiol Sect, Coll Med, Chicago, IL 60612 USA Univ Illinois Chicago IL USA 60612 Sect, Coll Med, Chicago, IL 60612 USA Univ Illinois, Dept Physiol & Biophys, Chicago, IL 60612 USA Univ Illinois Chicago IL USA 60612 ysiol & Biophys, Chicago, IL 60612 USA Midwestern Univ, Dept Physiol, Downers Grove, IL 60515 USA Midwestern Univ Downers Grove IL USA 60515 l, Downers Grove, IL 60515 USA
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
fascicolo: 1, volume: 281, anno: 2001,
pagine: C342 - C349
SICI:
0363-6143(200107)281:1<C342:AEONOD>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEPENDENT PROTEIN-KINASE; VENTRICULAR MYOCYTES; CYCLIC-GMP; MYOCARDIAL-CONTRACTILITY; SARCOPLASMIC-RETICULUM; HYDROGEN-PEROXIDE; HEART-FAILURE; CA2+ CURRENT; TROPONIN-I; PHOSPHOLAMBAN;
Keywords:
3-morpholino-sydnonimine; phospholamban; troponin I; beta-adrenergic stimulation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Wolska, BM Univ Illinois, Dept Med, Cardiol Sect, Coll Med, M-C 787,840 S Wood St, Chicago, IL 60612 USA Univ Illinois M-C 787,840 S Wood St Chicago IL USA 60612 12 USA
Citazione:
M.O. Stojanovic et al., "Anti-adrenergic effects of nitric oxide donor SIN-1 in rat cardiac myocytes", AM J P-CELL, 281(1), 2001, pp. C342-C349

Abstract

We studied how the nitric oxide (NO.) donor 3-morpholinosydnonimine (SIN-1) alters the response to beta -adrenergic stimulation in cardiac rat myocytes. We found that SIN-1 decreases the positive inotropic effect of isoproterenol (Iso) and decreases the extent of both cell shortening and Ca2+ transient. These effects of SIN-1 were associated with an increased intracellular concentration of cGMP, a decreased intracellular concentration of cAMP, and a reduction in the levels of phosphorylation of phospholamban (PLB) and troponin I (TnI). The guanylyl cyclase inhibitor 1H-8-bromo-1,2,4-oxadiazolo (3,4-d) benz(b)(1,4) oxazin-1-one (ODQ) was not able to prevent the SIN-1-induced reduction of phosphorylation levels of PLB and TnI. However, the effects of SIN-1 were abolished in the presence of superoxide dismutase (SOD) or SOD and catalase. These data suggest that, in the presence of Iso, NO-related congeners, rather than NO., are responsible for SIN-1 effects. Our results provide new insights into the mechanism by which SIN-1 alters the positive inotropic effects of beta -adrenergic stimulation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 09:33:17