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Titolo:
Characterization of human prostate mast cells and their increase in periprostatic vein thrombosis
Autore:
Bankl, HC; Samorapoompichit, P; Pikula, B; Latinovic, L; Bankl, H; Lechner, K; Valent, P;
Indirizzi:
Univ Vienna, Dept Clin Pathol, A-3010 St Poelten, Austria Univ Vienna St Poelten Austria A-3010 Pathol, A-3010 St Poelten, Austria Univ Vienna, Dept Internal Med 1, Div Hematol & Hemostaseol, A-3010 St Poelten, Austria Univ Vienna St Poelten Austria A-3010 taseol, A-3010 St Poelten, Austria Univ Vienna, Inst Histol & Embryol, A-3010 St Poelten, Austria Univ Vienna St Poelten Austria A-3010 mbryol, A-3010 St Poelten, Austria Univ Banja Luka, Dept Pathol, Banja Luka, Bosnia & Herceg Univ Banja LukaBanja Luka Bosnia & Herceg Banja Luka, Bosnia & Herceg Krankenhaus St Peolten, Inst Clin Pathol, St Peolten, Austria Krankenhaus St Peolten St Peolten Austria n Pathol, St Peolten, Austria
Titolo Testata:
AJCP. American journal of clinical pathology
fascicolo: 1, volume: 116, anno: 2001,
pagine: 97 - 106
Fonte:
ISI
Lingua:
ENG
Soggetto:
MULTIPLE BODY SITES; FACTOR KIT-LIGAND; FUNCTIONAL-CHARACTERIZATION; AURICULAR THROMBOSIS; BONE-MARROW; TRYPTASE; HETEROGENEITY; CHYMASE; TISSUE; SUSCEPTIBILITY;
Keywords:
prostate mast cells; periprostatic vein thrombosis; fibrinolysis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Bankl, HC Univ Vienna, Dept Clin Pathol, Probst Fuehrer Str 4, A-3010 St Poelten, Austria Univ Vienna Probst Fuehrer Str 4 St Poelten Austria A-3010tria
Citazione:
H.C. Bankl et al., "Characterization of human prostate mast cells and their increase in periprostatic vein thrombosis", AM J CLIN P, 116(1), 2001, pp. 97-106

Abstract

Recent data suggest that mast cells (MCs) and their products are involved in the pathophysiology, of thrombosis. In the present study, we analyzed the number distribution, and phenotype of prostate MCs and periprostatic MCs in patients with unilateral periprostatic vein thrombosis (PVT) by immunohistochemical analysis and electron microscopy. MCs reacted with monoclonal antibodies to tryptase, chymase, and c-kit/CD117 and stained positively for tissue-type plasminogen activator (tPA) and urokinase receptor (uPAR/CD87) but did not express detectable urokinase (uPA) or plasminogen activator inhibitors (PAI-1, PAI-2). We found an increase in the mean c SEM number of MCs in PVT compared with control (PVT 14.36 +/- 1.57 vs control, 5.23 +/- 0.57/mm(2)). The majority of MCs accumulated in the adventitia of thrombosed veins and showed a decrease in chymase expression. As MCs increase in numberin PVT and express a profibrinolytic phenotype, we hypothesize that MC-derived molecules have a role in endogenous fibrinolysis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 07:35:21