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Titolo:
Lymphoplasmacytic lymphoma/Waldenstrom macroglobulinemia associated with Hodgkin disease - A report of two cases
Autore:
Rosales, CM; Lin, P; Mansoor, A; Bueso-Ramos, C; Medeiros, LJ;
Indirizzi:
Univ Texas, MD Anderson Canc Ctr, Div Pathol & Lab Med, Houston, TX 77030 USA Univ Texas Houston TX USA 77030 v Pathol & Lab Med, Houston, TX 77030 USA
Titolo Testata:
AJCP. American journal of clinical pathology
fascicolo: 1, volume: 116, anno: 2001,
pagine: 34 - 40
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHRONIC LYMPHOCYTIC-LEUKEMIA; EPSTEIN-BARR-VIRUS; WALDENSTROMS-MACROGLOBULINEMIA; IMMUNOBLASTIC LYMPHOMA; CELL; TRANSFORMATION; MALIGNANCIES; COEXISTENT;
Keywords:
lymphoplasmacytic lymphoma; Waldenstrom macroglobulinemia; Hodgkin disease; bone marrow; lymph node; immunohistochemistry;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
C.M. Rosales et al., "Lymphoplasmacytic lymphoma/Waldenstrom macroglobulinemia associated with Hodgkin disease - A report of two cases", AM J CLIN P, 116(1), 2001, pp. 34-40

Abstract

Although the clinical course of lymphoplasmacytic lymphoma (LPL)/Waldenstrom macroglobulinemia (WM) is usually indolent, high-grade non-Hodgkin lymphoma may develop in a small subset of patients. We have not found any patients with LPL/WM associated with Hodgkin disease (HD) described in the literature, prompting us to report 2 cases. In case 1, the patient had LPL/WM involving bone marrow; diagnosed 1 week before left supraclavicular lymph nodebiopsy revealed LPL/WM and classical HD. In case 2, the patient had a 15-year history of LPL/WM before classical HD developed involving bone marrow, liver; and lymph node. Both cases were positive for IgM, monotypic immunoglobulin light chain, and B-cell antigens and were CD3-, The neoplastic Hodgkin cells were CD15+, CD20+ (case 1), CD30+, CD3-, and CD45- and were negative for Epstein-Barr virus RNA. Both patients were treated with chemotherapyfor HD. in case 1, clinical response was excellent with no histologic evidence of HD in subsequent biopsy specimens. In case 2, HD was progressive atInst follow-tip, despite therapy. Patients with LPL/WM; similar to patients with other types of low-grade B-cell lymphoma, can develop HD that may respond to chemotherapy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 23:03:05