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Titolo:
Plasma total homocysteine and cardiovascular and noncardiovascular mortalily: the Hordaland Homocysteine Study
Autore:
Vollset, SE; Refsum, H; Tverdal, A; Nygard, O; Nordrehaug, JE; Tell, GS; Ueland, PM;
Indirizzi:
Univ Bergen, Sect Med Stat, N-5021 Bergen, Norway Univ Bergen Bergen Norway N-5021 n, Sect Med Stat, N-5021 Bergen, Norway Haukeland Univ Hosp, Dept Heart Dis, N-5021 Bergen, Norway Haukeland Univ Hosp Bergen Norway N-5021 eart Dis, N-5021 Bergen, Norway Natl Hlth Screening Serv, Oslo, Norway Natl Hlth Screening Serv Oslo Norway Hlth Screening Serv, Oslo, Norway
Titolo Testata:
AMERICAN JOURNAL OF CLINICAL NUTRITION
fascicolo: 1, volume: 74, anno: 2001,
pagine: 130 - 136
SICI:
0002-9165(200107)74:1<130:PTHACA>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
SERUM TOTAL HOMOCYSTEINE; CORONARY HEART-DISEASE; RISK FACTOR; VASCULAR-DISEASE; MYOCARDIAL-INFARCTION; ELDERLY MEN; ALL-CAUSE; HYPERHOMOCYSTEINEMIA; DETERMINANTS; STROKE;
Keywords:
total homocysteine; cardiovascular mortality; noncardiovascular mortality; Hordaland Homocysteine Study; all-cause mortality; cardiovascular disease risk;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Vollset, SE Univ Bergen, Sect Med Stat, Armauer Hansens Hus, N-5021 Bergen, Norway Univ Bergen Armauer Hansens Hus Bergen Norway N-5021 , Norway
Citazione:
S.E. Vollset et al., "Plasma total homocysteine and cardiovascular and noncardiovascular mortalily: the Hordaland Homocysteine Study", AM J CLIN N, 74(1), 2001, pp. 130-136

Abstract

Background: Few population-based studies have assessed relations between plasma or serum total homocysteine (tHcy) and all-cause mortality. Objective: Our goal was to study associations between plasma tHcy and all-cause, cardiovascular, and noncardiovascular mortality. Design: This was a prospective cohort study of 2127 men and 2639 women aged 65-67 y in 1992-1993 when they were recruited as part of a population-based national cardiovascular screening program carried out in Hordaland County, Norway. Results: During a median of 4.1 y of follow-up, 162 men and 97 women died. A strong relation was found between plasma tHcy and all-cause mortality. The association was highly significant for noncardiovascular and for cardiovascular causes of death. In a comparison of individuals having tHcy concentrations of 9.0-11.9, 12.0-14.9, 15.0-19.9, or greater than or equal to 20 mu mol/L with individuals having a tHcy concentration <9 <mu>mol/L, adjustedmortality ratios were 1.4, 1.9, 2.3, and 3.6 (P for trend = 0.0002) for noncardiovascular and 1.3, 2.1, 2.6, and 3.5 (P for trend = 0.0002) for cardiovascular causes of death. A tHcy increment of 5 mu mol/L was associated with a 49% (95% CI: 28%, 72%) increase in all-cause mortality, a 50% (95% CI:21%, 85%) increase in cardiovascular mortality (121 deaths), a 26% (95% CI: -2%, 63%) increase in cancer mortality (103 deaths), and a 104% (95% CI: 44%, 289%) increase in noncancer, noncardiovascular mortality (33 deaths). Conclusion: plasma tHcy is a strong predictor of both cardiovascular and noncardiovascular mortality in a general population of 65-72-y-olds. These results should encourage studies of tHcy in a wider perspective than one confined to cardiovascular disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 09:19:09