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Titolo:
MORPHOGENS AND PATTERN-FORMATION
Autore:
NEUMANN C; COHEN S;
Indirizzi:
EUROPEAN MOL BIOL LAB,MEYERHOFSTR 1 D-69117 HEIDELBERG GERMANY
Titolo Testata:
BioEssays
fascicolo: 8, volume: 19, anno: 1997,
pagine: 721 - 729
SICI:
0265-9247(1997)19:8<721:MAP>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELL-CELL COMMUNICATION; DORSAL-VENTRAL PATTERN; DROSOPHILA EMBRYO; SIGNALING PATHWAY; LOCAL APPLICATION; WINGLESS PROTEIN; BICOID PROTEIN; RETINOIC ACID; GENE-PRODUCT; FLOOR PLATE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
75
Recensione:
Indirizzi per estratti:
Citazione:
C. Neumann e S. Cohen, "MORPHOGENS AND PATTERN-FORMATION", BioEssays, 19(8), 1997, pp. 721-729

Abstract

Morphogen gradient theories have enjoyed considerable popularity since the beginning of this century, but conclusive evidence for a role ofmorphogens in controlling multicellular development has been elusive. Recently, work on three secreted signalling proteins, Activin in Xenopus, and Wingless and Dpp in Drosophila, has stongly suggested that these proteins function as morphogens. In order to define a factor as a morphogen, it is necessary to show firstly that it has a direct effecton target cells and secondly, that it affects the development of target cells in a concentration-dependent manner. With these criteria in mind, the evidence available for a variety of proposed morphogens is discussed. While the evidence is not conclusive in most of the cases considered, there is a strong case in favour of the three proteins mentioned above, which suggests that morphogens are potentially of general importance in controlling the development of multicellular organisms.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 22:11:05