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Titolo:
MOLECULAR ASPECTS OF THE EPITHELIAL PHENOTYPE
Autore:
DAVIES JA; GARROD DR;
Indirizzi:
UNIV EDINBURGH,SCH MED,DEPT ANAT,TEVIOT PL EDINBURGH EH8 9AG MIDLOTHIAN SCOTLAND UNIV MANCHESTER,SCH BIOL SCI MANCHESTER M13 9PT LANCS ENGLAND
Titolo Testata:
BioEssays
fascicolo: 8, volume: 19, anno: 1997,
pagine: 699 - 704
SICI:
0265-9247(1997)19:8<699:MAOTEP>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELL-ADHESION MOLECULES; MESENCHYME-LIKE CELLS; LAMININ-A-CHAIN; KIDNEY DEVELOPMENT; LENS EPITHELIUM; COLLAGEN GELS; N-CADHERIN; EXPRESSION; EMBRYO; TRANSFORMATION;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
54
Recensione:
Indirizzi per estratti:
Citazione:
J.A. Davies e D.R. Garrod, "MOLECULAR ASPECTS OF THE EPITHELIAL PHENOTYPE", BioEssays, 19(8), 1997, pp. 699-704

Abstract

Epithelia can be defined morphologically as tissues that line surfaces, and ultrastructurally with reference to their cells' apico-basal polarity and possession of specific cell-cell junctions. Defining the epithelial phenotype at a molecular level is more problematic - while itis easy to name proteins (e.g. keratins) expressed by a 'typical' epithelium, no known molecules are expressed by every epithelium but by no other tissues. Cells can differentiate to and from the epithelial state as part of normal development, as a response to disease or when manipulated in culture. Many factors (matrix components, adhesion molecules, growth factors, transcription factors) have been identified that can trigger these transitions of phenotype in specific cases, but to date no general master regulators of the epithelial state have been found. The epithelial state may therefore be controlled by multiple regulatory genes so that there is no single molecule responsible for all ofthe diverse types of epithelium that exist in higher animals.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/11/20 alle ore 21:59:41