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Titolo:
Influence of early and current environmental exposure factors on sensitization and outcome of asthma in pre-school children
Autore:
Melen, E; Wickman, M; Nordvall, SL; van Hage-Hamsten, M; Lindfors, A;
Indirizzi:
Karolinska Hosp, Dept Environm Hlth, SE-17176 Stockholm, Sweden KarolinskaHosp Stockholm Sweden SE-17176 th, SE-17176 Stockholm, Sweden Karolinska Inst, Inst Environm Med, S-10401 Stockholm, Sweden Karolinska Inst Stockholm Sweden S-10401 Med, S-10401 Stockholm, Sweden Sachs Childrens Hosp, Dept Paediat, Stockholm, Sweden Sachs Childrens Hosp Stockholm Sweden , Dept Paediat, Stockholm, Sweden Univ Uppsala, Dept Womens & Childrens Hlth, Uppsala, Sweden Univ Uppsala Uppsala Sweden pt Womens & Childrens Hlth, Uppsala, Sweden Karolinska Hosp, Dept Med, Div Clin Immunol & Allergy, S-10401 Stockholm, Sweden Karolinska Hosp Stockholm Sweden S-10401 ergy, S-10401 Stockholm, Sweden Karolinska Hosp, Astrid Lindgren Childrens Hosp, Stockholm, Sweden Karolinska Hosp Stockholm Sweden gren Childrens Hosp, Stockholm, Sweden
Titolo Testata:
ALLERGY
fascicolo: 7, volume: 56, anno: 2001,
pagine: 646 - 652
SICI:
0105-4538(200107)56:7<646:IOEACE>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHILDHOOD ASTHMA; RISK-FACTORS; INDOOR ALLERGENS; BRONCHIAL HYPERRESPONSIVENESS; RESPIRATORY SYMPTOMS; ATOPIC SENSITIZATION; CAT ALLERGEN; PREVALENCE; PETS; REACTIVITY;
Keywords:
asthma; cat allergen; children; environmental tobacco smoke; exposure; risk factors; sensitization;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Melen, E Karolinska Hosp, Dept Environm Hlth, Norrbacka Bldg, SE-17176 Stockholm, Sweden Karolinska Hosp Norrbacka Bldg Stockholm Sweden SE-17176 Sweden
Citazione:
E. Melen et al., "Influence of early and current environmental exposure factors on sensitization and outcome of asthma in pre-school children", ALLERGY, 56(7), 2001, pp. 646-652

Abstract

Background: Exposure to furred pets in early life has been considered to increase the risk of allergic sensitization and consequent development of asthma later in children. However, recently, it has been suggested that earlyexposure to pets prevents sensitization. The aim of this study was to evaluate the importance of early exposure to pets and other environmental risk factors in asthmatic children. Methods: This is a follow-up study after 2 years of a previously investigated group of 193 asthmatic children, aged 1-4 years. The study was completed by 181 children, who were clinically examined; serum IgE antibodies were also measured and a questionnaire was answered. Results: Children with reported exposure to cats during the first 2 years of life were more likely to have developed sensitization to cat by 4 years of age than unexposed children. High levels of cat allergen (Fel d 1 greater than or equal to8 mug/g dust) were associated with an increased risk of sensitization to cat and, in combination with tobacco smoke, also with the development of more severe asthma. Conclusions: In young asthmatic children, early exposure to cat and tobacco smoke increased the risk of allergic sensitization and further development of more severe asthma later in childhood.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 05:29:21