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Titolo:
Nicotinamide adenine dinucleotide-dependent retinoic acid formation from retinol in the human gastric mucosa: Inhibition by ethanol, acetaldehyde, and H2 blockers
Autore:
Yokoyama, H; Matsumoto, M; Shiraishi, H; Miyagi, M; Kato, S; Ishii, H;
Indirizzi:
Keio Univ, Sch Med, Dept Internal Med, Shinjuku Ku, Tokyo 1608582, Japan Keio Univ Tokyo Japan 1608582 nal Med, Shinjuku Ku, Tokyo 1608582, Japan
Titolo Testata:
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
fascicolo: 6, volume: 25, anno: 2001, supplemento:, S
pagine: 24S - 28S
SICI:
0145-6008(200106)25:6<24S:NADRAF>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN STOMACH ALCOHOL; ALDEHYDE DEHYDROGENASES; HUMAN-LIVER; SUBSTRATE-SPECIFICITY; MOLECULAR-CLONING; EXPRESSION; OXIDATION; RECEPTORS; SEQUENCE; CDNA;
Keywords:
stomach; retinoids; histamine receptor blocker;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Yokoyama, H Keio Univ, Sch Med, Dept Internal Med, Shinjuku Ku, 35 Shinanomachi, Tokyo1608582, Japan Keio Univ 35 Shinanomachi Tokyo Japan 1608582 o1608582, Japan
Citazione:
H. Yokoyama et al., "Nicotinamide adenine dinucleotide-dependent retinoic acid formation from retinol in the human gastric mucosa: Inhibition by ethanol, acetaldehyde, and H2 blockers", ALC CLIN EX, 25(6), 2001, pp. 24S-28S

Abstract

All-trans retinoic acid formation from all-trans retinol (vitamin A) in the human gastric mucosa was studied. When all-trans retinol and the human gastric mucosa were incubated together, all-trans retinoic acid was formed inthe presence of nicotinamide adenine dinucleotide (NAD). When the NAD was not added, hardly any formation was observed. The formation of all-trans retinoic acid tended to be attenuated by 10 mM ethanol. Moreover, it was significantly attenuated in a concentration-dependent manner by ethanol at concentrations of LOO mM and above. Acetaldehyde at concentrations of 50 muM and above also significantly attenuated its formation in a concentration-dependent manner. Some H2 blockers, which include ranitidine hydrochloride and cimetidine, significantly attenuated the formation of all-trans retinoic acid, whereas famotidine failed to suppress it. There is an NAD-dependent pathway by which all-trans retinoic acid is produced from all-trans retinol inthe human gastric mucosa. Inhibitors of alcohol dehydrogenase, which include ethanol and some H2 blockers, and of aldehyde dehydrogenase, which include acetaldehyde, inhibit its production.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 03:13:47