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Titolo:
Differences in sensitivity to the aversive effects of ethanol in low-alcohol drinking (UChA) and high-alcohol drinking (UChB) rats
Autore:
Quintanilla, ME; Callejas, O; Tampier, L;
Indirizzi:
Univ Chile, Fac Med, ICBM, Program Mol & Clin Pharmacol, Santiago 7, ChileUniv Chile Santiago Chile 7 gram Mol & Clin Pharmacol, Santiago 7, Chile
Titolo Testata:
ALCOHOL
fascicolo: 3, volume: 23, anno: 2001,
pagine: 177 - 182
SICI:
0741-8329(200104)23:3<177:DISTTA>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
GENETIC-FACTORS; ACUTE TOLERANCE; TASTE-AVERSION; ACETALDEHYDE; LINES;
Keywords:
conditioned taste aversion; oral alcohol preference; alcohol aversion;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Quintanilla, ME Univ Chile, Fac Med, ICBM, Program Mol & Clin Pharmacol, POB 70-000, Santiago 7, Chile Univ Chile POB 70-000 Santiago Chile 7 Santiago 7, Chile
Citazione:
M.E. Quintanilla et al., "Differences in sensitivity to the aversive effects of ethanol in low-alcohol drinking (UChA) and high-alcohol drinking (UChB) rats", ALCOHOL, 23(3), 2001, pp. 177-182

Abstract

A conditioned taste aversion paradigm was used to determine whether aversion to the pharmacological effects of ethanol, apart from orosensory cues, can contribute to differences in voluntary ethanol consumption in rats of the low-alcohol drinking (UChA) and the high-alcohol drinking (UChB) strains. "Alcohol-naive" UChA and UChB rats were injected intraperitoneally with ethanol (0.5, 1.0, 1.5, or 2.0 g/kg) or saline, paired with consumption of a banana-flavored solution during five conditioning trials. Repeated pairingsof banana-flavored solution and ethanol at a dose of 1.5 g/kg produced aversion to the banana-flavored solution in UChA rats, but not in UChB rats, at comparable blood ethanol levels. In addition, the highest dose of ethanoltested (2.0 g/kg) produced stronger aversion to the banana-flavored solution in UChA rats, compared with findings in UChB rats. From these results itis suggested that rats of the UChA strain find the postingestional effectsof high-dose ethanol more aversive than do UChB rats. Differences in voluntary ethanol consumption seem to be associated with differences in sensitivity to the aversive effects of ethanol. (C) 2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/04/20 alle ore 12:03:06