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Titolo:
Full-length sequences of two CRF01_AE (Subtype E) HIV type 1 isolates from1995 samples of patients with sexually transmitted diseases in Thailand
Autore:
Auwanit, W; Mukai, T; Ayuthaya, PIN; Kurata, T; Ikuta, K;
Indirizzi:
Osaka Univ, Microbial Dis Res Inst, Dept Virol, Suita, Osaka 5650871, Japan Osaka Univ Suita Osaka Japan 5650871 t Virol, Suita, Osaka 5650871, Japan Minist Publ Hlth, Dept Med Sci, Nonthaburi 11000, Thailand Minist Publ Hlth Nonthaburi Thailand 11000 i, Nonthaburi 11000, Thailand Hokkaido Univ, Inst Immunol Sci, Sect Serol, Kita Ku, Sapporo, Hokkaido 0600815, Japan Hokkaido Univ Sapporo Hokkaido Japan 0600815 oro, Hokkaido 0600815, Japan Natl Inst Infect Dis, Dept Pathol, Shinjuku Ku, Tokyo 1628655, Japan Natl Inst Infect Dis Tokyo Japan 1628655 injuku Ku, Tokyo 1628655, Japan
Titolo Testata:
AIDS RESEARCH AND HUMAN RETROVIRUSES
fascicolo: 9, volume: 17, anno: 2001,
pagine: 867 - 871
SICI:
0889-2229(200106)17:9<867:FSOTC(>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
IMMUNODEFICIENCY-VIRUS TYPE-1; V3 REGION; IN-VIVO;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: Mukai, T Osaka Univ, Microbial Dis Res Inst, Dept Virol, 3-1 Yamadaoka, Suita, Osaka 5650871, Japan Osaka Univ 3-1 Yamadaoka Suita Osaka Japan 5650871 5650871, Japan
Citazione:
W. Auwanit et al., "Full-length sequences of two CRF01_AE (Subtype E) HIV type 1 isolates from1995 samples of patients with sexually transmitted diseases in Thailand", AIDS RES H, 17(9), 2001, pp. 867-871

Abstract

We isolated two CRF01_AE human immunodeficiency virus type 1 (95TNIH022 and 95TNIH047) from the 1995 blood samples derived from asymptomatic carriersin Ubonratchatani province of northeastern Thailand. Both isolates can replicate in peripheral blood mononuclear cells, but not in several T cell lines examined. The full-length sequences recovered from proviruses in infected cells by long-range polymerase chain reaction were determined. Phylogenetic analyses of these sequences at individual genes showed them to be closely related to those of reported CRF01_AE HIV-1, such as 1990 isolate CM240 and 1993 isolate 93TH253. Two isolates in this study also showed a similar pattern of CRF01_AE mosaicism and a similar structure at the long terminal repeat, i.e., a copy number of NF-kappaB binding sites, sequence at the TATAbox, and the putative secondary structure of stem-loop in the transactivation response region. Our results showed that 1995 Thai E isolates could contribute to our understanding of the epidemiology, pathogenesis, and diagnostics of HIV-1 CRF01_AE and further to vaccine development.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 22:12:28