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Titolo:
CONCENTRATIONS OF INDOLEAMINE METABOLIC INTERMEDIATES IN THE VENTRICULAR CEREBROSPINAL-FLUID OF ADVANCED PARKINSONS PATIENTS WITH SEVERE POSTURAL INSTABILITY AND GAIT DISORDERS
Autore:
IACONO RP; KUNIYOSHI SM; AHLMAN JR; ZIMMERMAN GJ; MAEDA G; PEARLSTEIN RD;
Indirizzi:
LOMA LINDA UNIV,MED CTR,DIV NEUROSURG,11234 ANDERSON ST,RM 2539 LOMA LINDA CA 92350
Titolo Testata:
Journal of neural transmission
fascicolo: 4-5, volume: 104, anno: 1997,
pagine: 451 - 459
SICI:
0300-9564(1997)104:4-5<451:COIMII>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
DISEASE; SEROTONIN; DOPAMINE; NEURONS; TRYPTOPHAN; TYROSINE; LUMBAR; HPLC;
Keywords:
SEROTONIN; PARKINSONS DISEASE; POSTURAL INSTABILITY; CEREBROSPINAL FLUID (CSF);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
R.P. Iacono et al., "CONCENTRATIONS OF INDOLEAMINE METABOLIC INTERMEDIATES IN THE VENTRICULAR CEREBROSPINAL-FLUID OF ADVANCED PARKINSONS PATIENTS WITH SEVERE POSTURAL INSTABILITY AND GAIT DISORDERS", Journal of neural transmission, 104(4-5), 1997, pp. 451-459

Abstract

Postural instability and gait disorders (PIGD) are the primary causesof disability in many but not all advanced Parkinson's disease (PD) patients. We have measured the concentrations of serotonin, 5-hydroxytryptophan (5-HTP), 5-hydroxy-3-indoleacetic acid (5-HIAA), and homovanillic acid (HVA) in samples of ventricular cerebrospinal fluid from tenPD patients with severe disability from PIGD and from ten PD patientswith tremor and levodopa induced dyskinesia as their predominant motor dysfunction. The two groups were prospectively matched for duration of disease and age. No significant differences between the two groups were found in the concentration (mean +/- SD in ng/ml, PIGD dominant vs. tremor-dyskinesia dominant) of 5-HIAA (106 +/- 50 vs. 99 +/- 34) orHVA (1,068 +/- 595 vs. 881 +/- 469). Serotonin concentration was significantly lower (0.7 +/- 0.5 vs. 1.5 +/- 0.9) and 5-HTP concentration was substantially higher (684 +/- 1,054 vs. 6 +/- 5) in the patient group with PIGD as their predominant symptoms. Thus, the distinguishing feature of patients with severe PIGD appears to be a derangement in indoleamine metabolism at the reaction step catalyzed by aromatic amino acid decarboxylase (AADC). These findings suggest that aggravation of PIGD in advanced Parkinson's may be related in part to impaired serotonergic transmission secondary to inhibition or down regulation of AADC.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 09:11:03