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Titolo:
AMPHETAMINE EFFECTS ON DOPAMINE RELEASE AND SYNTHESIS RATE STUDIED INTHE RHESUS-MONKEY BRAIN BY POSITRON EMISSION TOMOGRAPHY
Autore:
HARTVIG P; TORSTENSON R; TEDROFF J; WATANABE Y; FASTH KJ; BJURLING P; LANGSTROM B;
Indirizzi:
UNIV UPPSALA HOSP,PET CTR S-75185 UPPSALA SWEDEN UNIV UPPSALA HOSP,HOSP PHARM S-75185 UPPSALA SWEDEN UNIV UPPSALA HOSP,DEPT NEUROL S-75185 UPPSALA SWEDEN RES DEV CORP JAPAN,SUBFEMTOMOLE BIORECOGNIT PROJECT TSUKUBA IBARAKI JAPAN
Titolo Testata:
Journal of neural transmission
fascicolo: 4-5, volume: 104, anno: 1997,
pagine: 329 - 339
SICI:
0300-9564(1997)104:4-5<329:AEODRA>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
BLOOD-FLOW; C-11 RACLOPRIDE; INTRAVENOUS (H2O)-O-15; INVIVO MICRODIALYSIS; ENDOGENOUS DOPAMINE; H-3 RACLOPRIDE; BINDING; PET; SUBSENSITIVITY; METABOLITES;
Keywords:
AMPHETAMINE; [C-11]; L-DOPA; RACLOPRIDE; N-METHYLSPIPERONE; CBF; PET; MONKEYS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
P. Hartvig et al., "AMPHETAMINE EFFECTS ON DOPAMINE RELEASE AND SYNTHESIS RATE STUDIED INTHE RHESUS-MONKEY BRAIN BY POSITRON EMISSION TOMOGRAPHY", Journal of neural transmission, 104(4-5), 1997, pp. 329-339

Abstract

Positron emission tomography (PET) was used in a multitracer protocolto evaluate D-amphetamine induced effects on dopamine biosynthesis rate and release in propofol anesthetized Rhesus monkeys. L-[beta-C-11]DOPA was used as biochemical probe to study the brain dopamine biosynthesis rate whilst dopamine release was followed by the binding displacement of the [C-11]-radiolabelled dopamine receptor antagonists, raclopride and N-methylspiperone. Studies were performed with either a constant rate intravenous infusion of D-amphetamine aiming at plasma concentrations of 0.2 to 25 ng/ml or with intravenous bolus doses of 0.1 and0.4 mg/kg. Decreased binding of the dopamine receptor antagonists wasmeasured in both modes of D-amphetamine administration but notably [C-11]N-methylspiperone was less able to sense D-amphetamine induced release of dopamine. At plasma concentrations aimed above 1 ng/ml a levelling off of the binding of [C-11]raclopride at 68 +/- 8.1% of the baseline value indicated that displacement was only possible from a fraction of the binding sites. Amphetamine was observed to increase the rateconstant for L-[beta-C-11]DOPA utilization in the brain. This was most likely due to an acutely induced subsensitivity of presynaptic dopamine receptors. L-[(beta-C-11]DOPA and [C-11]raclopride were found suitable to indicate changes in dopamine synthesis rate and release respectively using PET and can be used to mirror drug-induced changes of brain dopaminergic function.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 18:56:24