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Titolo:
Intranasal immunogenicity of a Delta cya Delta crp-pabA mutant of Salmonella enterica serotype Typhimurium for the horse
Autore:
Sheoran, AS; Timoney, JF; Tinge, SA; Sundaram, P; Curtiss, R;
Indirizzi:
Univ Kentucky, Dept Vet Sci, Gluck Equine Res Ctr, Lexington, KY 40546 USAUniv Kentucky Lexington KY USA 40546 ine Res Ctr, Lexington, KY 40546 USA MEGAN Hlth, St Louis, MO 63110 USA MEGAN Hlth St Louis MO USA 63110MEGAN Hlth, St Louis, MO 63110 USA
Titolo Testata:
VACCINE
fascicolo: 27, volume: 19, anno: 2001,
pagine: 3787 - 3795
SICI:
0264-410X(20010614)19:27<3787:IIOADC>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
SHIGELLA-FLEXNERI 2A; MONOCLONAL-ANTIBODIES; ESCHERICHIA-COLI; ADENYLATE-CYCLASE; IMMUNE-RESPONSES; LYMPHOID-TISSUE; LIVE; VACCINES; VACCINATION; LIPOPOLYSACCHARIDE;
Keywords:
horse; nasal mucosal; intranasal; antibody isotype; Salmonella enterica serotype Typhimurium;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Timoney, JF Univ Kentucky, Dept Vet Sci, Gluck Equine Res Ctr, Lexington, KY 40546 USA Univ Kentucky Lexington KY USA 40546 Lexington, KY 40546 USA
Citazione:
A.S. Sheoran et al., "Intranasal immunogenicity of a Delta cya Delta crp-pabA mutant of Salmonella enterica serotype Typhimurium for the horse", VACCINE, 19(27), 2001, pp. 3787-3795

Abstract

The aim of this study was to investigate the intranasal immunogenicity forthe horse of a Delta cya Delta crp-pabA mutant (MGN-707) of Salmonella enteric a serotype Typhimurium (S. tryphimurium). MGN-707 caused no sign of disease, was not detected in feces and a single administration induced strongSalmonella-specific serum and nasal mucosal antibody responses. All ponieshad made strong salmonella specific serum IgGa. IgGb. IEA and IgM antibodyresponses by day 25 after the first immunization. IgM responses to salmonella lipopolysaccharide (LPS) were short lived whereas salmonella specific serum IgGa and IgGb persisted at high levels in all ponies until 83 and 140 days, respectively. Specific nasal mucosal antibody responses dominated by IEA and IgM were evident by day 25 in all ponies except one in which only specific IgGa and IgGb were evident. Specific nasal mucosal IgA persisted inmost ponies until day 69. A second immunization on day 140 boosted antibody responses, and stimulated a strong nasal mucosal IgA response in the ponythat failed to make an IgA response after primary immunization. At the termination of the experiment, IgA and IgGb dominated jejunal antibody responses whereas vaginal responses were mainly IgA. The latter response unequivocally confirms the existence of a common mucosal immune system in equids. The results: indicate that a S. typhimurium Delta cya Delta crp-pabA mutant has potential as an intranasal vaccine against salmonellosis in the horst. (C) 2001 Elsevier Science Ltd, All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/07/20 alle ore 22:05:57