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Titolo:
Absence of microsatellite instability and germline mutations of E-cadherin, APC and p53 genes in Japanese familial gastric cancer
Autore:
Kusano, M; Kakiuchi, H; Mihara, M; Itoh, F; Adachi, Y; Ohara, M; Hosokawa, M; Imai, K;
Indirizzi:
Sapporo Med Univ, Dept Internal Med 1, Chuo Ku, Sapporo, Hokkaido 0608543,Japan Sapporo Med Univ Sapporo Hokkaido Japan 0608543 o, Hokkaido 0608543,Japan Keiyukai Sapporo Hosp, Dept Surg, Sapporo, Hokkaido, Japan Keiyukai Sapporo Hosp Sapporo Hokkaido Japan g, Sapporo, Hokkaido, Japan
Titolo Testata:
TUMOR BIOLOGY
fascicolo: 4, volume: 22, anno: 2001,
pagine: 262 - 268
SICI:
1010-4283(200107/08)22:4<262:AOMIAG>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
NONPOLYPOSIS COLORECTAL-CANCER; ADENOMATOUS POLYPOSIS; SUPPRESSOR GENE; IDENTIFICATION; POPULATION; HISTORY; BREAST; CHROMOSOME-5Q21; STOMACH; RISK;
Keywords:
familial gastric cancer; hereditary nonpolyposis colorectal cancer microsatellite instability; transforming growth factor-beta receptor type II; E-cadherin; familial adenomatous polyposis; Li-Fraumeni syndrome;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Kakiuchi, H Sapporo Med Univ, Dept Internal Med 1, Chuo Ku, S-1 W-16, Sapporo, Hokkaido 0608543, Japan Sapporo Med Univ S-1 W-16 Sapporo Hokkaido Japan 0608543 Japan
Citazione:
M. Kusano et al., "Absence of microsatellite instability and germline mutations of E-cadherin, APC and p53 genes in Japanese familial gastric cancer", TUMOR BIOL, 22(4), 2001, pp. 262-268

Abstract

To evaluate the genetic factors of familial predisposition to gastric cancer, genetic alterations in the surgically resected stomach samples from gastric-cancer-prone families were investigated. Familial gastric cancer (FGC)was defined as gastric cancer occurring in a family with 3 or more gastriccancer patients over at least two successive generations. We examined replication error(RER) of six microsatellite markers and screened mutations of the 10-(A) repeat sequence in the transforming growth factor-p receptor type II ( TGF-beta RII gene in individuals from seven unrelated FGC families. Three cases showed RER at one of the six (CA)n microsatellite markers but the other 4 cases showed no RER at any of these loci. No mutation was found in the 10-(A) repeat of the TGF-beta RII gene. Additionally, no germline mutation was found by polymerase chain reaction-single strand conformation polymorphism in exons 1-16 of E-cadherin, exons 5-8 of p53 and in the mutation cluster region of APC. These results indicate that disorders in the DNA mismatch repair system, E-cadherin, p53 and APC may be infrequently involvedin the carcinogenesis of Japanese FGC, Copyright (C) 2001 S. Karger AG, Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 04:23:42