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Titolo:
Retinoic acids reduce matrilysin (Matrix metalloproteinase 7) and inhibit tumor cell invasion in human colon cancer
Autore:
Adachi, Y; Itoh, F; Yamamoto, H; Iku, S; Matsuno, K; Arimura, Y; Imai, K;
Indirizzi:
Sapporo Med Univ, Dept Internal Med 1, Chuo Ku, Sapporo, Hokkaido 0608543,Japan Sapporo Med Univ Sapporo Hokkaido Japan 0608543 o, Hokkaido 0608543,Japan
Titolo Testata:
TUMOR BIOLOGY
fascicolo: 4, volume: 22, anno: 2001,
pagine: 247 - 253
SICI:
1010-4283(200107/08)22:4<247:RARM(M>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN COLORECTAL CANCERS; MESSENGER-RNA; ALL-TRANS; EXTRACELLULAR-MATRIX; EXPRESSION; PURIFICATION; SUPPRESSION; METABOLISM; CARCINOMA; MMP-7;
Keywords:
inhibition; invasion; human colon cancer; matrilysin (MMP-7); retinoic acids; all-trans retinoic acid; 9-cis retinoic acid; 13-cis retinoic acid; SCID mice;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Itoh, F Sapporo Med Univ, Dept Internal Med 1, Chuo Ku, South 1,West 16, Sapporo, Hokkaido 0608543, Japan Sapporo Med Univ South 1,West 16 Sapporo Hokkaido Japan 0608543 an
Citazione:
Y. Adachi et al., "Retinoic acids reduce matrilysin (Matrix metalloproteinase 7) and inhibit tumor cell invasion in human colon cancer", TUMOR BIOL, 22(4), 2001, pp. 247-253

Abstract

All-trans retinoic acid (ATRA), g-cis retinoic acid and 13-cis retinoic acid are naturally occurring retinoids used in the prevention and therapy of various preneoplastic and neoplastic diseases. It was previously reported that matrilysin, one of the matrix metalloproteinases (MMP-7), plays a critical role in the invasion and metastasis of gastrointestinal cancers. Moreover, it has been shown that ATRA downregulates matrilysin expression and prevents in vitro invasion by colon cancer cells. In this study, three retinoids were used, both in Matrigel invasion assays and in subcutaneous xenografts in mice, to evaluate the effects of retinoids on invasion by colon cancer cell lines (CHC-Y1, DLD-1, HT-29, BM314, CaR-1 and WiDr). All three retinoic acids tested reduced matrilysin expression and suppressed the invasiveness of colon cancer cell lines in vitro. Retinoic acids also reduced tumor invasion in mice without influencing tumor growth. Matrilysin expression inthese tumors was clearly reduced. These data support the use of retinoic acids as useful reagents to manage patients with colorectal carcinoma. Copyright (C) 2001 S, Karger AG, Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 16/07/20 alle ore 19:59:17