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Titolo:
Elevated CA 125 in breast cancer - A sign of advanced disease
Autore:
Norum, LF; Erikstein, B; Nustad, K;
Indirizzi:
Norwegian Radium Hosp, Cent Lab, N-0310 Oslo, Norway Norwegian Radium Hosp Oslo Norway N-0310 , Cent Lab, N-0310 Oslo, Norway Norwegian Radium Hosp, Dept Oncol, N-0310 Oslo, Norway Norwegian Radium Hosp Oslo Norway N-0310 Dept Oncol, N-0310 Oslo, Norway
Titolo Testata:
TUMOR BIOLOGY
fascicolo: 4, volume: 22, anno: 2001,
pagine: 223 - 228
SICI:
1010-4283(200107/08)22:4<223:EC1IBC>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
CARCINOEMBRYONIC ANTIGEN; MONOCLONAL-ANTIBODIES; PLEURAL METASTASES; SERUM CA-125; CARCINOMA; INDICATOR; CA125; MARKERS; CA-15-3; ASSAYS;
Keywords:
CA 125; MUC1; CEA; breast cancer; pleura affection;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Norum, LF Norwegian Radium Hosp, Cent Lab, N-0310 Oslo, Norway Norwegian Radium Hosp Oslo Norway N-0310 , N-0310 Oslo, Norway
Citazione:
L.F. Norum et al., "Elevated CA 125 in breast cancer - A sign of advanced disease", TUMOR BIOL, 22(4), 2001, pp. 223-228

Abstract

The serum tumor markers CA 125, MUC1 and CEA were measured in 221 breast cancer patients over a period of 2 years, Patients examined on at least three occasions were included in the study. Thirty-three patients had increasing or continuously high concentrations of CA 125. Thirty (91%) of these had involvement of the pleura, either as pleural metastasis or metastasis in surrounding tissue i.e, bone structures in the thorax cavity or lung parenchyma. MUC1 and CEA were elevated in 27 (82%) and 24 (73%) of the 33 patients,respectively. Increased concentrations of these two markers did not relateto the site of metastasis. However, the three tumor markers complemented each other in detecting early metastases, Increased CA 125 was associated with metastasis in or near the pleura, and in stage IV breast cancer it was related to poor prognosis. Copyright (C) 2001 S. Karger AG Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/21 alle ore 04:44:45