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Titolo:
IMPACT OF HLA-H MUTATIONS ON IRON STORES IN HEALTHY ELDERLY MEN AND WOMEN
Autore:
GARRY PJ; MONTOYA GD; BAUMGARTNER RN; LIANG HC; WILLIAMS TM; BRODIE SG;
Indirizzi:
UNIV NEW MEXICO,SCH MED,DEPT PATHOL,CLIN NUTR PROGRAM,RM 215 SURGE BLDG ALBUQUERQUE NM 87131 UNIV NEW MEXICO,SCH MED,CTR POPULAT HLTH,CLIN NUTR PROGRAM ALBUQUERQUE NM 87131 UNIV NEW MEXICO,SCH MED,DEPT MED ALBUQUERQUE NM 87131 BURNS & ALLEN CEDARS SINAI RES INST,STEVEN SPIELBERG PEDIAT RES CTR,DIV MED GENET LOS ANGELES CA 90048
Titolo Testata:
Blood cells, molecules, & diseases
fascicolo: 14, volume: 23, anno: 1997,
pagine: 277 - 287
SICI:
1079-9796(1997)23:14<277:IOHMOI>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
BLOOD DONATIONS; POPULATION; ABSORPTION;
Keywords:
HLA-H; AGING; IRON STORES; PSAT; SERUM TRANSFERRIN SATURATION; SERUM FERRITIN; HEMOCHROMATOSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
19
Recensione:
Indirizzi per estratti:
Citazione:
P.J. Garry et al., "IMPACT OF HLA-H MUTATIONS ON IRON STORES IN HEALTHY ELDERLY MEN AND WOMEN", Blood cells, molecules, & diseases, 23(14), 1997, pp. 277-287

Abstract

The DNA of 287 healthy white elderly volunteers in the New Mexico Aging Process Study, between 63 and 91 years of age, was examined for mutations of the HLA-H gene at nt 845 and nt 187. None were found to be homozygous for the 845A mutation and there were no gender differences in the percentage of the various mutations, The frequency of the 845A mutation was 0.061 resulting in a carrier frequency of 12.2%. The frequency of the 187G mutation was 0.136 resulting in a carrier frequency of 19.9% for a single mutation; 2.4% were compound heterozygous, 845A/187G and 2.4% were homozygous for the 187G mutation. After excluding 5 men and 4 women with microcytic or macrocytic anemia, mean percent transferrin saturation (PSAT) and iron stores, as estimated from serum ferritin concentrations, were calculated for each mutation. Estimated iron stores were normally distributed (range similar to 50 to 1,550 mg) with men (n=111) having significantly higher mean estimated iron stores than women (n=167), 826+/-318 and 753+/-287 mg, respectively. More men, 15 of 28, (54%) with estimated iron stores in the upper quartile, greater than or equal to 1,050 mg, had a HLA-H mutation compared to 25of 83 (30%) who had a mutation and whose estimated iron stores were <1,050 mg, p<0.05, Seven were heterozygous for the 845A mutation with mean estimated iron stores of 1,300+/-127 mg, 7 were heterozygous for the 187G mutation with mean estimated iron stores of 1,233+/-165 mg and1 was compound heterozygous with estimated iron stores of 1,439 mg, Similar differences were not noted in women. Even though the potential role of the 187G mutation in the phenotypic expression of HH is less certain than the 845A mutation, the increase in PSAT seen in men with the 187G mutation and the equal distribution of 845A and 187G mutationsseen with iron stores greater than or equal to 1,050 mg lends supportfor the involvement of the 187G mutation, or a linked mutation, in iron metabolism. We concluded that men having either a single chromosomal 845A and/or 187G mutation results in higher PSAT's and estimated iron stores than if no HLA-H mutation were present.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 07:23:17