Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Analysis of the RGD sequence in protein structures: comparison to the conformations of the RGDW and (D)RGDW peptides determined by molecular dynamicssimulations
Autore:
Stote, RH;
Indirizzi:
Univ Strasbourg 1, ISIS, CNRS, ESA 7006,Lab Chim Biophys, F-67000 Strasbourg, France Univ Strasbourg 1 Strasbourg France F-67000 , F-67000 Strasbourg, France
Titolo Testata:
THEORETICAL CHEMISTRY ACCOUNTS
fascicolo: 1-2, volume: 106, anno: 2001,
pagine: 128 - 136
SICI:
1432-881X(200106)106:1-2<128:AOTRSI>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
ARG-GLY-ASP; NUCLEAR-MAGNETIC-RESONANCE; HIGH-AFFINITY LIGANDS; BLUETONGUE VIRUS VP7; D-XYLOSE ISOMERASE; HEPATITIS-C VIRUS; X-RAY-ANALYSIS; CRYSTAL-STRUCTURE; 3-DIMENSIONAL STRUCTURE; HUMAN FIBRONECTIN;
Keywords:
RGD; conformation; molecular dynamics; cell adhesion;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Citazioni:
69
Recensione:
Indirizzi per estratti:
Indirizzo: Stote, RH Univ Strasbourg 1, ISIS, CNRS, ESA 7006,Lab Chim Biophys, 4 Rue Blaise Pascal, F-67000 Strasbourg, France Univ Strasbourg 1 4 Rue Blaise Pascal Strasbourg France F-67000
Citazione:
R.H. Stote, "Analysis of the RGD sequence in protein structures: comparison to the conformations of the RGDW and (D)RGDW peptides determined by molecular dynamicssimulations", THEOR CH AC, 106(1-2), 2001, pp. 128-136

Abstract

Geometric properties of the RGD sequence in a data set of protein crystal and NMR structures deposited in the Protein Data Bank were examined to identify structural characteristics that are related to cell adhesion activity. Interatomic distances and dihedral angles are examined. These geometric measures are then used in an analysis of the conformations of the RGDW and (D)RGDW peptides obtained from molecular dynamics simulations (Stote RH, et al. (2000) J Phys Chem B 104:1624). This analysis leads to the suggestion that differences in the accessible conformations contribute to the differencein biological activity between the RGDW and the,RGDW peptides.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 16:02:59