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Titolo:
Acute neuroleptic stimulates DOPA decarboxylase in porcine brain in vivo
Autore:
Danielsen, EH; Smith, D; Hermansen, F; Gjedde, A; Cumming, P;
Indirizzi:
Aarhus Kommune Hosp, PET Ctr, DK-8000 Aarhus, Denmark Aarhus Kommune HospAarhus Denmark DK-8000 Ctr, DK-8000 Aarhus, Denmark Risskov Hosp, Dept Biol Psychiat, Aarhus, Denmark Risskov Hosp Aarhus Denmark v Hosp, Dept Biol Psychiat, Aarhus, Denmark
Titolo Testata:
SYNAPSE
fascicolo: 2, volume: 41, anno: 2001,
pagine: 172 - 175
SICI:
0887-4476(200108)41:2<172:ANSDDI>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMINO-ACID DECARBOXYLASE; POSITRON-EMISSION-TOMOGRAPHY; LIVING HUMAN BRAIN; RAT-BRAIN; IN-VIVO; TYROSINE-HYDROXYLASE; PARKINSONS-DISEASE; HALOPERIDOL; MODULATION; METABOLISM;
Keywords:
[F-18]fluorodopa; DOPA decarboxylase levodopa; regulation; neuroleptics; haloperidol; Parkinson's disease;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Cumming, P Aarhus Kommune Hosp, PET Ctr, DK-8000 Aarhus, Denmark Aarhus Kommune Hosp Aarhus Denmark DK-8000 00 Aarhus, Denmark
Citazione:
E.H. Danielsen et al., "Acute neuroleptic stimulates DOPA decarboxylase in porcine brain in vivo", SYNAPSE, 41(2), 2001, pp. 172-175

Abstract

The activity of DOPA decarboxylase measured in homogenates from rat striatum, or calculated from the rate of tracer decarboxylation measured ex vivo,is stimulated following acute treatment with antagonists of dopamine D2-like receptors. We used compartmental kinetics to test the hypothesis that utilization of the DOPA decarboxylase substrate [F-18]fluorodopa is potentiated in living striatum following acute treatment with a typical neuroleptic. The kinetics of the tracer uptake were determined in eight anesthetized female pigs (40 kg) and in three animals receiving an infusion of haloperidol(75 mug kg(-1) h(-1)) for 1 h prior to tracer administration and throughout the 2-h positron emission recording. The relative activity of DOPA decarboxylase in striatum was increased threefold by the treatment. This potentiation of DOPA decarboxylation after pharmacological blockade of dopamine D2-like receptors may be used to optimize the utilization of exogenous DOPA inthe treatment of Parkinson's disease. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 13:59:54