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Titolo:
Cholinergic synaptic potentials in the supragranular layers of auditory cortex
Autore:
Bandrowski, AE; Moore, SL; Ashe, JH;
Indirizzi:
Univ Calif Riverside, Dept Cell Biol & Neurosci, Riverside, CA 92521 USA Univ Calif Riverside Riverside CA USA 92521 osci, Riverside, CA 92521 USA Univ Calif Riverside, Dept Psychol, Program Neurosci, Riverside, CA 92521 USA Univ Calif Riverside Riverside CA USA 92521 osci, Riverside, CA 92521 USA
Titolo Testata:
SYNAPSE
fascicolo: 2, volume: 41, anno: 2001,
pagine: 118 - 130
SICI:
0887-4476(200108)41:2<118:CSPITS>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXCITATORY POSTSYNAPTIC POTENTIALS; CORTICAL ACETYLCHOLINE-RELEASE; MUSCARINIC RECEPTOR SUBTYPES; HIPPOCAMPAL PYRAMIDAL CELLS; NUCLEUS BASALIS; CEREBRAL-CORTEX; NEOCORTICAL NEURONS; FIELD PLASTICITY; MEDIATED EPSP; RAT NEOCORTEX;
Keywords:
synaptic; ACh; glutamate; chloride; GABA-A; GABA-B;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
62
Recensione:
Indirizzi per estratti:
Indirizzo: Ashe, JH Univ Calif Riverside, Dept Cell Biol & Neurosci, Riverside, CA 92521 USA Univ Calif Riverside Riverside CA USA 92521 erside, CA 92521 USA
Citazione:
A.E. Bandrowski et al., "Cholinergic synaptic potentials in the supragranular layers of auditory cortex", SYNAPSE, 41(2), 2001, pp. 118-130

Abstract

Receptive-field plasticity within the auditory neocortex is associated with learning, memory, and acetylcholine (ACh). However, the interplay of elements involved in changing receptive-fields remains unclear. Herein, we describe a depolarizing and a hyperpolarizing potential elicited by repetitive stimulation (20-100 Hz, 0.5-2 sec) and dependent on ACh, which may be involved in modifying receptive-fields. These potentials were recorded, using whole cell techniques, in layer II/III pyramidal cells in the rat auditory cortex in vitro. Stimulation at low stimulus intensities can give rise to a hyperpolarizing response and stimulation at higher stimulus intensities can elicit a depolarizing response. The depolarizing response had a reversal potential of -35 mV, and was reduced by the combination of AMPA/kainate and NMDA glutamate receptor antagonists (AMPA/kainate: CNQX, DNQX, and GYKI 52466; NMDA: APV, MK-801) and by the muscarinic ACh receptor antagonist atropine. The hyperpolarizing response had a reversal potential of -73 mV and could be reduced by atropine, GABAA receptor antagonists (bicuculline and a Cl-channel blocker picrotoxin), and to a small, extent a GABAB receptor antagonist (saclofen). This suggests that the hyperpolarizing response is likelyto be mediated by ACh acting on GABAergic interneurons. Extracellular recordings, also made from layer II/III of cortical slices, yielded a negative-going potential which was reduced by ionotropic glutamate receptor antagonists (same as above) and by the ACh receptor antagonists atropine and scopolamine, suggesting that this potential was the extracellular representation of the depolarizing response. (C) 2001 Wiley-Liss, Inc.

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Documento generato il 01/04/20 alle ore 20:35:10