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Titolo:
Effect of endogenous dopamine on extrastriatal [C-11]FLB 457 binding measured by PET
Autore:
Okauchi, T; Suhara, T; Maeda, J; Kawabe, K; Obayashi, S; Suzuki, K;
Indirizzi:
Natl Inst Radiol Sci, Div Adv Technol Med Imaging, Chiba 2638555, Japan Natl Inst Radiol Sci Chiba Japan 2638555 d Imaging, Chiba 2638555, Japan Japan Sci & Technol Corp, CREST, Kawaguchi, Saitama 3320012, Japan Japan Sci & Technol Corp Kawaguchi Saitama Japan 3320012 a 3320012, Japan SHI Accelerator Serv Ltd, Tokyo 1418686, Japan SHI Accelerator Serv Ltd Tokyo Japan 1418686 v Ltd, Tokyo 1418686, Japan
Titolo Testata:
SYNAPSE
fascicolo: 2, volume: 41, anno: 2001,
pagine: 87 - 95
SICI:
0887-4476(200108)41:2<87:EOEDOE>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; C-11 RACLOPRIDE BINDING; IN-VIVO BINDING; SYNAPTIC DOPAMINE; RECEPTOR-BINDING; MONKEY BRAIN; D-2 RECEPTOR; D-2-DOPAMINE RECEPTORS; STRIATAL DOPAMINE; NONHUMAN-PRIMATES;
Keywords:
[C-11]FLB 457; [C-11]raclopride; endogenous dopamine; extrastriatal dopamine D-2 receptor; methamphetamine; nonhuman primate; positron emission tomography;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Suhara, T Natl Inst Radiol Sci, Div Adv Technol Med Imaging, 4-9-1 Anagawa, Chiba 2638555, Japan Natl Inst Radiol Sci 4-9-1 Anagawa Chiba Japan 2638555 5, Japan
Citazione:
T. Okauchi et al., "Effect of endogenous dopamine on extrastriatal [C-11]FLB 457 binding measured by PET", SYNAPSE, 41(2), 2001, pp. 87-95

Abstract

Central dopaminergic systems are known to be implicated in the pathophysiology of schizophrenia and recent in vivo dopamine receptor imaging studies have focused on the measurement of extrastriatal dopamine receptor. However, there are only a limited number of ligands that can measure the low-density D, receptor in extrastriatal regions and their sensitivity to endogenousdopamine in extrastriatal regions has not yet been fully examined. In thisstudy, the effect of endogenous dopamine on the extrastriatal binding of [C-11]FLB 457 was examined in the rhesus monkey after facilitation with 1 mg/kg of methamphetamine (MAP) and was compared with the effect on the striatal binding of [C-11]raclopride. The indices of receptor binding were obtained by four methods using cerebellum as a reference region. The bindings of [C-11]FLB 457 in the frontal cortex, temporal cortex, and thalamus were notsignificantly changed after MAP treatment, while the striatal binding of [C-11]raclopride was decreased by more than 20%. These results suggest that [C-11]FLB 457 is not sensitive to endogenous dopamine in the extrastriatal regions of rhesus monkeys, despite a sufficient dose of MAP to decrease thebinding of [C-11]raclopride in the striatum. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 00:40:21