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Titolo:
The importance of peripheral blood leukocytes and macrophage infiltration on bronchial wall wound healing in rats treated preoperatively with anticancer agents
Autore:
Shirafuji, T; Oka, T; Sawada, T; Tamura, K; Kishimoto, K; Yamamoto, S; Nagayasu, T; Takahashi, T; Ayabe, H;
Indirizzi:
Nagasaki Univ, Sch Med, Dept Surg 1, Nagasaki 8528501, Japan Nagasaki Univ Nagasaki Japan 8528501 ept Surg 1, Nagasaki 8528501, Japan
Titolo Testata:
SURGERY TODAY
fascicolo: 4, volume: 31, anno: 2001,
pagine: 308 - 316
SICI:
0941-1291(2001)31:4<308:TIOPBL>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELL LUNG-CANCER; FIBROBLAST GROWTH-FACTOR; BRONCHOPLASTIC PROCEDURES; SLEEVE LOBECTOMY; ADRIAMYCIN; ETOPOSIDE; SURVIVAL; INVIVO; CYCLOPHOSPHAMIDE; DOXORUBICIN;
Keywords:
wound healing; bronchial anastomosis; induction chemotherapy; macrophage; rat; tissue repair;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Ayabe, H Nagasaki Univ, Sch Med, Dept Surg 1, 1-7-1 Sakamoto, Nagasaki 8528501, Japan Nagasaki Univ 1-7-1 Sakamoto Nagasaki Japan 8528501 28501, Japan
Citazione:
T. Shirafuji et al., "The importance of peripheral blood leukocytes and macrophage infiltration on bronchial wall wound healing in rats treated preoperatively with anticancer agents", SURG TODAY, 31(4), 2001, pp. 308-316

Abstract

Preoperative chemotherapy is commonly used for small cell lung cancer or advanced non-small cell lung cancer. This study was conducted to investigatethe effects of preoperative antineoplastic agents on the postoperative would healing of bronchial anastomoses in a rat model. Cisplatin (CDDP), doxorubicin (ADM), or cyclophosphamide (CPA) was administered either 3 days preoperatively (experiment 1) or 7 days preoperatively (experiment 2). Wound healing was assessed on postoperative days (POD) 3, 5, and 7 after anastomosis of the bronchus, by examining the bursting strength and hydroxyproline tissue content. In experiment 1, significant impairment of wound healing was seen on POD 3 in the CPA-treated rats, but no significant changes were seenin the other groups. Severe leukopenia and marked reduction of macrophage infiltration into the wound were also observed in the CPA-treated rats. Theimpairment of wound healing coincided with the time of leukopenia and reduced macrophage infiltration into the wounds. In experiment 2, induction chemotherapy did not impair wound healing. Our experimental results suggest that preoperative chemotherapy producing mild leukopenia, or when followed bya sufficient interval to allow for the recovery of myelosuppression, did not impair wound healing of the bronchial anastomoses. The findings of this study also showed that the depletion of macrophages at the anastomotic siteis one of the most important causes of impaired wound healing.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 07:19:49