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Titolo:
Relationship of the factor structure of psychopathology in schizophrenia to the timing of initial intervention with antipsychotics
Autore:
Meagher, D; Quinn, J; Murphy, P; Kinsella, A; Mullaney, J; Waddington, JL;
Indirizzi:
St Davnets Hosp, Stanley Fdn Res Unit, Monaghan, Ireland St Davnets Hosp Monaghan Ireland tanley Fdn Res Unit, Monaghan, Ireland St Itas Hosp, Portrane, County Dublin, Ireland St Itas Hosp Portrane County Dublin Ireland rane, County Dublin, Ireland St Lomans Hosp, Mullingar, County Westmeat, Ireland St Lomans Hosp Mullingar County Westmeat Ireland ounty Westmeat, Ireland Dublin Inst Technol, Dept Math, Dublin 8, Ireland Dublin Inst Technol Dublin Ireland 8 chnol, Dept Math, Dublin 8, Ireland Royal Coll Surg Ireland, Dept Clin Pharmacol, Dublin 2, Ireland Royal CollSurg Ireland Dublin Ireland 2 in Pharmacol, Dublin 2, Ireland
Titolo Testata:
SCHIZOPHRENIA RESEARCH
fascicolo: 1-2, volume: 50, anno: 2001,
pagine: 95 - 103
SICI:
0920-9964(20010530)50:1-2<95:ROTFSO>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
FIRST-EPISODE SCHIZOPHRENIA; GENDER DIFFERENCES; NEGATIVE SYMPTOMS; COGNITIVE IMPAIRMENT; PSYCHOSIS; ONSET; LIFETIME; DISEASE; DYSFUNCTION; DIMENSIONS;
Keywords:
factor structure; initially unmedicated psychosis; psychomotor poverty; psychopathology; schizophrenia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Waddington, JL St Davnets Hosp, Stanley Fdn Res Unit, Monaghan, Ireland StDavnets Hosp Monaghan Ireland Unit, Monaghan, Ireland
Citazione:
D. Meagher et al., "Relationship of the factor structure of psychopathology in schizophrenia to the timing of initial intervention with antipsychotics", SCHIZOPHR R, 50(1-2), 2001, pp. 95-103

Abstract

Timing of intervention with antipsychotic medication may influence long-term outcome in schizophrenia in a manner that is poorly understood. This study evaluated psychopathology, its factor structure, and cognitive dysfunction in older patients with chronic schizophrenia in relation to the intervals from onset of psychosis to initiation of treatment with antipsychotics, and from initiation of antipsychotic treatment to current assessments. The subjects were 129 patients with schizophrenia, many of whom became ill in the preneuroleptic era. Their current psychopathology was assessed using the Positive and Negative Syndrome Scale, and its factor structure examined using principal component analysis. Current general and executive cognitive function was evaluated using the Mini-Mental State Examination and the Executive Interview, respectively. Using multiple regression modelling, increasing duration of initially unmedicated psychosis, but not the much longer duration of subsequently treated illness, was the primary predictor of psychomotor poverty (negative symptoms) but not of reality distortion or disorganisation over the three domains of psychopathology resolved; duration of initially unmedicated psychosis marginally predicted the severity of general, but not of executive, cognitive dysfunction. Delayed intervention with antipsychotics appears associated with poorer long-term course in terms of increased severity of psychopathology in the psychomotor poverty domain. (C) 2001Elsevier Science B.V. All rights: reserved.

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Documento generato il 25/02/20 alle ore 08:13:33