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Titolo:
Risperidone versus haloperidol in long-term hospitalized chronic patients in a double blind randomized trial: a post hoc analysis
Autore:
Rabinowitz, J; Davidson, M;
Indirizzi:
Bar Ilan Univ, IL-52100 Ramat Gan, Israel Bar Ilan Univ Ramat Gan IsraelIL-52100 Univ, IL-52100 Ramat Gan, Israel Tel Aviv Univ, IL-69978 Tel Aviv, Israel Tel Aviv Univ Tel Aviv Israel IL-69978 v Univ, IL-69978 Tel Aviv, Israel
Titolo Testata:
SCHIZOPHRENIA RESEARCH
fascicolo: 1-2, volume: 50, anno: 2001,
pagine: 89 - 93
SICI:
0920-9964(20010530)50:1-2<89:RVHILH>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
SCHIZOPHRENIC-PATIENTS; EFFICACY; OLANZAPINE; BIAS;
Keywords:
haloperidol; post hoc analysis; risperidone; schizophrenia treatment;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Rabinowitz, J Bar Ilan Univ, IL-52100 Ramat Gan, Israel Bar Ilan Univ Ramat Gan Israel IL-52100 Ramat Gan, Israel
Citazione:
J. Rabinowitz e M. Davidson, "Risperidone versus haloperidol in long-term hospitalized chronic patients in a double blind randomized trial: a post hoc analysis", SCHIZOPHR R, 50(1-2), 2001, pp. 89-93

Abstract

Background: Patients who remain in hospital for an extended time pose a special therapeutic: challenge. Objectives: The goal of this study was to examine whether the acute response of long-term hospitalized schizophrenic patients differs between haloperidol and risperidone based on a post hoc, sub-analysis of data from a large double blind pivotal trial. Method: Data on chronic schizophrenic patients who had been hospitalized for at least 60 days (median 351 days) prior to entering this 8-week randomized double blind controlled trial were examined. This included 75 patients treated with 4 mg of risperidone and 69 treated with 10 mg of haloperidol. Changes in symptoms were assessed with the Positive and Negative Syndrome Scale for Schizophrenia (PANSS) and the Clinical Global Impression (CGI). Data were analyzed using analysis of variance. Results: The analyses revealed that patients receiving risperidone improved significantly more than those treated with haloperidol. Conclusions: Results suggest that the most often prescribed dose of risperidone. 4 mg, might be more effective for long-stay chronic schizophrenic patients than haloperidol 10 mg. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/11/19 alle ore 02:46:41